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  Retention of dopamine 2 receptor mRNA and absence of the protein in craniospinal and extracranial metastasis of a malignant prolactinoma: a case report

Winkelmann, J., Pagotto, U., Theodoropoulou, M., Tatsch, K., Saeger, W., Müller, A., et al. (2002). Retention of dopamine 2 receptor mRNA and absence of the protein in craniospinal and extracranial metastasis of a malignant prolactinoma: a case report. European Journal of Endocrinology, 146(1), 81-88.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A26D-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A26E-2
Genre: Journal Article
Alternative Title : Eur. J. Endocrinol.

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 Creators:
Winkelmann, J1, Author
Pagotto, U1, Author
Theodoropoulou, M1, Author
Tatsch, K1, Author
Saeger, W1, Author
Müller, A1, Author
Arzberger, T1, Author
Schaaf, L1, Author
Schumann, EM1, Author
Trenkwalder, C1, Author
Stalla, GK1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Abstract: Objectives: The case presented here describes the clinical evolution of a malignant prolactinoma with occurrence of intra- and extra-cranial metastases. In this case, the presence of dopamine 2 receptor (D2R) was studied at the mRNA and protein level, in order to understand the pathological background of the resistance to treatment with different dopamine agonists. Design: Together with an extensive description of the clinical history of this case, a combination of in vitro and in vivo techniques was performed to provide the basis of the dopamine resistance developed in the course of the disease. Method: A comparison of the D2R was performed in specimens obtained at presentation of the disease compared with autoptic specimens derived from local invasion and metastasis using in situ hybridization and immunohistochemical techniques. Results: Intact D2R mRNA was found in the primitive tumor and metastatic tissues, whereas protein for the same receptor was present only in the tissues derived from neurosurgical operations and not in the metastases obtained post-mortem. Conclusion: This is the first report of the absence of D2R protein despite the retention of the transcript in an advanced stage of a malignant prolactinoma. The findings of this single case suggest the hypothesis that postranscriptional mechanisms may contribute to the development of dopamine resistance in prolactinoma

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Language(s): eng - English
 Dates: 2002-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4056
ISI: 000178742700013
 Degree: -

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Title: European Journal of Endocrinology
  Alternative Title : Eur. J. Endocrinol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 146 (1) Sequence Number: - Start / End Page: 81 - 88 Identifier: ISSN: 0804-4643