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  Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13

Deussing, J., Kouadio, M., Rehman, S., Werber, I., Schwinde, A., & Peters, C. (2002). Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Genomics, 79(2), 225-240.

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Genre: Zeitschriftenartikel
Alternativer Titel : Genomics

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 Urheber:
Deussing, J1, Autor
Kouadio, M1, Autor
Rehman, S1, Autor
Werber, I1, Autor
Schwinde, A1, Autor
Peters, C1, Autor
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Schlagwörter: cysteine peptidase; C1A family; cathepsin; PAC-contig; placenta-specific; chromosome 13; gene cluster
 Zusammenfassung: Genes encoding novel murine cysteine peptidases of the papain family C1A and related genes were cloned and mapped to mouse chromosome 13, colocalizing with the previously assigned cathepsin J gene. We constructed a < 460-kb phage artificial chromosome (PAC) contig and characterized a dense cluster comprising eight CIA cysteine peptidase genes, cathepsins J, M, Q R, -1, -2, -3, and -6; three pseudogenes of cathepsins M, -1, and -2; and four genes encoding putative cysteine peptidase inhibitors related to the proregion of C1A peptidases (trophoblast-specific proteins and alpha and beta cytotoxic T- lymphocyte-associated proteins 2alpha and -beta). Because of sequence homologies of 61.9-72.0% between cathepsin J and the other seven putative cysteine peptidases of the cluster, these peptidases are classified as "cathepsin J-like." The absence of cathepsin J-like peptidases and related genes from the human genome suggests that the cathepsin J cluster arose by partial and complete gene duplication events after the divergence of primate and rodent lineages. The expression of cathepsin J-like peptidases and related genes in the cluster is restricted to the placenta only. Clustered genes are induced at specific time points, and their expression increases toward the end of gestation. The specific expression pattern and high expression level suggest an essential role of cathepsin J-like peptidases and related genes in formation and development of the murine placenta

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Sprache(n): eng - English
 Datum: 2002-02
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 4200
ISI: 000173628100012
 Art des Abschluß: -

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Titel: Genomics
  Alternativer Titel : Genomics
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 79 (2) Artikelnummer: - Start- / Endseite: 225 - 240 Identifikator: ISSN: 0888-7543