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  Endocrine rhythms in patients with restless legs syndrome

Wetter, T., Collado-Seidel, V., Oertel, H., Uhr, M., Yassouridis, A., & Trenkwalder, C. (2002). Endocrine rhythms in patients with restless legs syndrome. Journal of Neurology, 249(2), 146-151.

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Genre: Journal Article
Alternative Title : J. Neurol.

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 Creators:
Wetter, TC1, Author
Collado-Seidel, V1, Author
Oertel, H1, Author
Uhr, M1, Author
Yassouridis, A1, Author
Trenkwalder, C1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: restless legs syndrome; prolactin; growth hormone; cortisol; polysomnography
 Abstract: There is increased evidence that the dopaminergic system plays a major role in the pathophysiology of the restless legs syndrome (RLS). Dopamine is the major inhibitory factor of prolactin release and also influences growth hormone (hGH) secretion. The aim of this study was to measure the endocrine activity of RLS patients, to compare it with that of normal subjects and to detect possibly altered patterns of hormonal secretion in RLS patients. Prolactin, hGH and cortisol plasma levels were measured every 20 min for 24 hours in 10 male never-medicated RLS patients (aged 56 +/- 6 years) who have had mild to moderate symptoms for 15 +/- 10 years and in 8 age- matched male controls (aged 57 +/- 5 years). The blood samples taken during the night were paralleled by polysomnographic recordings including the assessment of periodic leg movements (PLM). Plasma levels as well as frequency and amplitude of the pulses of prolactin, hGH and cortisol were not different between RLS patients and controls. Both groups showed the same rhythms during the night and daytime for all hormones. Cross correlations resulted in high correlation coefficients for each hormone at lag 0 (0.964, 0.943 and 0.971 for mean locations of cortisol, hGH and prolactin, respectively). Concerning sleep parameters, there were no significant differences between the two groups apart from a higher PLMS arousal index in RLS patients (25.9 +/- 17.1) compared with the controls (12.0 +/- 9.2; p < 0.05). It is suggested that a possible dysfunction of the dopaminergic system in RLS does not affect the release of prolactin and hGH from the pituitary glan

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Language(s): eng - English
 Dates: 2002-02
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4192
ISI: 000173979800003
 Degree: -

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Title: Journal of Neurology
  Alternative Title : J. Neurol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 249 (2) Sequence Number: - Start / End Page: 146 - 151 Identifier: ISSN: 0340-5354