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  The effects of the neuroactive steroid 3α , 5α- THDOC on sleep in the rat

Müller-Preuss, P., Rupprecht, R., & Lancel, M. (2002). The effects of the neuroactive steroid 3α, 5α- THDOC on sleep in the rat. NeuroReport, 13(4), 487-490.

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Genre: Journal Article
Alternative Title : Neuroreport

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 Creators:
Müller-Preuss, P1, Author
Rupprecht, R1, Author
Lancel, M1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: allopregnanolone; EEG spectral analysis; GABA(A) receptor; neuroactive steroids; sleep; THDOC
 Abstract: This vehicle-controlled study assessed the sleep effects of the naturally occurring neuroactive steroid 3alpha 5alpha- tetrahydrodeoxycorticosterone (3alpha,5alpha-THDOC; 7.5 and 15 mg/kg), administered i.p. to rats, and compared them with those of another neuroactive steroid allopregnanolone (IS mg/kg). 3alpha,5alpha-THDOC shortened sleep latency, selectively promoted pre-REMS (a transitional state between non-REMS and REMS) and lengthened the non-REMS episodes dose-dependently. Spectral analysis of the EEG within nonREMS found significant attenuations of low-frequency activity and elevations in the spindle and higher frequency bands. The effects of 3alpha,5alpha-THDOC closely match those of allopregnanolone, indicating a common mechanism of action. Since the sleep changes produced by these steroids resemble the sleep profile of benzodiazepine hypnotics, they are probably caused by a positive allosteric modulation of GABA(A) receptor functi

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Language(s): eng - English
 Dates: 2002-03-25
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4179
ISI: 000174971300026
 Degree: -

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Title: NeuroReport
  Alternative Title : Neuroreport
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 13 (4) Sequence Number: - Start / End Page: 487 - 490 Identifier: ISSN: 0959-4965