日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細

登録内容を編集ファイル形式で保存
 
 
ダウンロード電子メール
 タグ情報を表示リリース履歴を表示詳細要約
  Effects of supraphysiological thyroxine administration in healthy controls and patients with depressive disorders

Bauer, M., Baur, H., Berghöfer, A., Ströhle, A., Hellweg, R., Müller-Oerlinghausen, B., & Baumgartner, A. (2002). Effects of supraphysiological thyroxine administration in healthy controls and patients with depressive disorders. Journal of Affective Disorders, 68(2-3), 285-294.

Item is

 

表示: 全項目 非表示: 全項目

基本情報

表示: 非表示:
アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000E-A22D-5 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000E-A22E-3
資料種別: 学術論文
その他のタイトル : J. Affect. Disord.

ファイル

表示: ファイル

関連URL

表示:

作成者

表示:
非表示:
 作成者:
Bauer, M.1, 著者
Baur, H1, 著者
Berghöfer, A1, 著者
Ströhle, A.1, 著者
Hellweg, R1, 著者
Müller-Oerlinghausen, B1, 著者
Baumgartner, A1, 著者
所属:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

内容説明

表示:
非表示:
キーワード: thyroxine; healthy controls; depression; safety; side effects
 要旨: Background: Thyroxine (T-4) in supraphysiological doses has been found to be an effective supplemental treatment in open studies for refractory mood disorders. Unexpectedly, only minimal side effects have been reported. The goal of the present study was to investigate whether healthy controls and depressed patients differ in their ability to tolerate supraphysiological doses of T-4. Methods: This was an 8-week open study to investigate side effects and levels of thyroid hormones in 13 healthy controls and to compare results with those of 13 patients with refractory depression (unipolar and bipolar) undergoing the similar procedures and T-4 closing regimen in a previous augmentation study. Results: The rate of discontinuation due to side effects was significantly higher in the control group than for the patients (38% versus 0%). The severity of the side effects in the controls increased significantly during treatment with T-4. The side effect scores of the patients were higher than those of the controls prior to T-4 treatment, but did not change significantly during the treatment period. Although the serum concentrations of thyroid hormones rose significantly in both groups, concentrations of fT(3) and fT(4) were significantly higher in the controls. Conclusions: Healthy controls and depressed patients respond significantly differently to supraphysiological T-4 Healthy controls experience higher elevations of thyroid hormones in response to supraphysiological T-4 thus inducing significantly more side effects and discontinuation. Limitations: Open-label study; groups were studied at different times; in contrast to healthy controls, depressed patients were also taking antidepressants. Clinical relevance: Studies provide safety and tolerability data on treatment with supraphysiological doses of T-4. (C) 2002 Elsevier Science BV. All rights reserved

資料詳細

表示:
非表示:
言語: eng - English
 日付: 2002-04
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: eDoc: 4135
ISI: 000176496500014
 学位: -

関連イベント

表示:

訴訟

表示:

Project information

表示:

出版物 1

表示:
非表示:
出版物名: Journal of Affective Disorders
  出版物の別名 : J. Affect. Disord.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 68 (2-3) 通巻号: - 開始・終了ページ: 285 - 294 識別子（ISBN, ISSN, DOIなど）: ISSN: 0165-0327