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  Restless legs syndrome probably induced by risperidone treatment

Wetter, T., Brunner, J., & Bronisch, T. (2002). Restless legs syndrome probably induced by risperidone treatment. Pharmacopsychiatry, 35(3), 109-111.

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Genre: Journal Article
Alternative Title : Pharmacopsychiatry

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 Creators:
Wetter, TC1, Author
Brunner, J1, Author
Bronisch, T1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Abstract: Background: According to some reports, patients treated with risperidone may develop akathisia. Restless legs syndrome (RLS), which shares some clinical features with akathisia, is a distinct movement and sleep disorder that may be induced by various drugs that act on the CNS. Methods: We studied a 31- year-old patient suffering from a schizoaffective disorder including auditory hallucinations who developed symptoms typical of the RLS during treatment with risperidone, using polysomnography to objectify sleep disturbances and associated periodic leg movements during sleep (PLMS). Results: After switching from clozapine to risperidone treatment, the patient complained about dysethesias primarily of the legs, an urge to walk around, and sleep disturbances. The latter could be confirmed by polysomnography, including an abnormal PLMS index. Risperidone was switched to haloperidol. However, RLS symptoms were still present. After switching to quetiapine, RLS symptoms vanished and a second polysomnography test demonstrated better sleep quality and normal PLMS measurements. During the whole treatment period with different neuroleptics, the patient additionally received valproic acid. Conclusions: Symptoms typical of RLS may be induced by risperidone treatment and should be differentiated from akathisia. Although polysomnography is not necessary, it may be helpful confirming the diagnosi

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Language(s): eng - English
 Dates: 2002-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4137
ISI: 000176262700005
 Degree: -

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Title: Pharmacopsychiatry
  Alternative Title : Pharmacopsychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 35 (3) Sequence Number: - Start / End Page: 109 - 111 Identifier: ISSN: 0176-3679