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  Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors

Sillaber, I., Rammes, G., Zimmermann, S., Mahal, B., Zieglgänsberger, W., Wurst, W., et al. (2002). Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science, 296(5569), 931-933.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A1E1-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A1E2-2
Genre: Journal Article
Alternative Title : Science

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 Creators:
Sillaber, I1, Author
Rammes, G1, Author
Zimmermann, S1, Author
Mahal, B1, Author
Zieglgänsberger, W1, Author
Wurst, W1, Author
Holsboer, F1, Author
Spanagel, R1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Abstract: There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior appeared with a delay and persisted throughout life. It was associated with an up-regulation of the N-methyl-D-aspartate receptor subunit NR2B. Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholis

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Language(s): eng - English
 Dates: 2002-05-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4170
ISI: 000175442500050
 Degree: -

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Title: Science
  Alternative Title : Science
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 296 (5569) Sequence Number: - Start / End Page: 931 - 933 Identifier: ISSN: 0036-8075