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  Mice overexpressing CRH show reduced responsiveness in plasma corticosterone after a5-HT1A receptor challenge

van Gaalen, M., Reul, J., Gesing, A., Stenzel-Poore, M., Holsboer, F., & Steckler, T. (2002). Mice overexpressing CRH show reduced responsiveness in plasma corticosterone after a5-HT1A receptor challenge. Genes Brain and Behavior, 1(3), 174-177.

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Genre: Journal Article
Alternative Title : Genes Brain Behav.

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 Creators:
van Gaalen, MM1, Author
Reul, JHM1, Author
Gesing, A1, Author
Stenzel-Poore, MP1, Author
Holsboer, F1, Author
Steckler, T1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: 8-OH DPAT-induced hypothermia; corticosterone; serotonin; CRH; 5HT(1A) receptor; stress-induced hyperthermia
 Abstract: Corticotropin-releasing hormone (CRH) overproduction and serotonergic dysfunction have both been implicated in a range of psychiatric disorders, such as anxiety and depression, and several studies have shown interactions between these two neurotransmitter systems. In this study, we investigated the effects of CRH challenge on hypothalamo-pituitary-adrenal (HPA) axis activity in female transgenic mice overproducing CRH. Furthermore, the effects of mild stress on HPA axis activity and body temperature were investigated in these mice. Pre- and post-synaptic 5-HT1A receptor function were studied by monitoring body temperature and plasma corticosterone levels after challenge with the 5-HT1A receptor agonist 8-hydroxy-2- (di-n-propyl-amino)-tetralin (8-OH-DPAT). Hypothermia in response to 8-OH-DPAT treatment did not differ between transgenic and wild type mice, indicating unaltered somatodendritic 5-HT1A autoreceptor function in mice overproducing CRH. In wild type mice 8-OH-DPAT increased plasma corticosterone levels, but not in transgenic animals. CRH injection, however, increased corticosterone levels in both groups. These data suggest desensitization of post-synaptic, but not pre-synaptic, 5-HT1A receptors in mice overproducing CRH. These findings resemble those seen in depressed patients following 5-HT1A challenge, which is in accord with the hypothesized role of CRH in the pathogenesis of depressio

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Language(s): eng - English
 Dates: 2002-08
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4044
ISI: 000178923000005
 Degree: -

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Title: Genes Brain and Behavior
  Alternative Title : Genes Brain Behav.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 1 (3) Sequence Number: - Start / End Page: 174 - 177 Identifier: ISSN: 1601-1848