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  The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat

Fischer, A., von Rosenstiel, P., Fuchs, E., Goula, D., Almeida, O., & Czeh, B. (2002). The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat. Brain Research, 947(2), 290-293.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A195-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A196-E
Genre: Journal Article
Alternative Title : Brain Res.

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 Creators:
Fischer, AK1, Author
von Rosenstiel, P1, Author
Fuchs, E1, Author
Goula, D1, Author
Almeida, OFX1, Author
Czeh, B1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: adrenalectomy; aldosterone; neurogenesis; hippocampus; dentate gyrus
 Abstract: Glucocorticoid receptor activation inhibits granule cell proliferation in the hippocampus. but little is known about the role of mineralocorticoid receptors in this process. Here we administered aldosterone to adrenalectomized (ADX) rats, and monitored neurogenesis by BrdU immunohistochemistry. ADX significantly increased the number of BrdU-positive cells and aldosterone replacement further augmented BrdU-positivity. Our results indicate that aldosterone, most probably acting through mineralocorticoid receptors, may positively influence the proliferation and survival of newly-generated granule cells. (C) 2002 Elsevier Science B.V. All rights reserved

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Language(s): eng - English
 Dates: 2002-08-30
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4087
ISI: 000178022100017
 Degree: -

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Title: Brain Research
  Alternative Title : Brain Res.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 947 (2) Sequence Number: - Start / End Page: 290 - 293 Identifier: ISSN: 0006-8993