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  Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families

Winkelmann, J., Müller-Myhsok, B., Wittchen, H., Hock, B., Prager, M., Pfister, H., et al. (2002). Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families. Annals of Neurology, 52(3), 297-302.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A169-5 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A16A-3
Genre: Zeitschriftenartikel
Alternativer Titel : Ann. Neurol.

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 Urheber:
Winkelmann, J1, Autor
Müller-Myhsok, B1, Autor
Wittchen, HU1, Autor
Hock, B1, Autor
Prager, M1, Autor
Pfister, H1, Autor
Ströhle, A1, Autor
Eisensehr, I1, Autor
Dichgans, M1, Autor
Gasser, T1, Autor
Trenkwalder, C1, Autor
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Zusammenfassung: A strong familial component of restless legs syndrome (RLS) is known. The objective of this study therefore was to investigate the likely mode of inheritance of RI-S. RLS patients and their first-degree relatives were investigated and classified in RLS affected and RI-S nonaffected subjects. Assessments were based on direct, personal standardized diagnostic interviews. Complex segregation analysis was performed with the families stratified according to the mean age at onset of the disease within the families. Two hundred thirty-eight RILS patients, 537 first- degree relatives, and 133 spouses were interviewed. Two groups of families were stratified: mean age at onset up to 30 years of age (Group A) and older than 30 years (Group B; p < 0.005). In Group A, segregation analysis strongly favored a single major gene acting autosomal dominant with a multifactorial component. Parameter estimates were 0.003 for the allele frequency, 1.0 for the penetrance, and 0.005 for the phenocopy rate. In Group B, no evidence for a major gene could be elucidated. The segregation pattern found in our families argues for an autosomal allele acting dominantly in RLS families with an early age at onset of symptoms and suggests that RLS is a causative heterogeneous dise

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Sprache(n): eng - English
 Datum: 2002-09
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 4095
ISI: 000177820100006
 Art des Abschluß: -

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Titel: Annals of Neurology
  Alternativer Titel : Ann. Neurol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 52 (3) Artikelnummer: - Start- / Endseite: 297 - 302 Identifikator: ISSN: 0364-5134