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  Repetitive transcranial magnetic stimulation (rTMS) in major depression: Relation between efficacy and stimulation intensity

Padberg, F., Zwanzger, P., Keck, M., Kathmann, N., Mikhaiel, P., Ella, R., et al. (2002). Repetitive transcranial magnetic stimulation (rTMS) in major depression: Relation between efficacy and stimulation intensity. Neuropsychopharmacology, 27(4), 638-645.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A14B-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A14C-7
Genre: Journal Article
Alternative Title : Neuropsychopharmacology

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 Creators:
Padberg, F1, Author
Zwanzger, P1, Author
Keck, ME1, Author
Kathmann, N1, Author
Mikhaiel, P1, Author
Ella, R1, Author
Rupprecht, P1, Author
Thoma, H1, Author
Hampel, H1, Author
Toschi, N1, Author
Möller, HJ1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: major depression; medication resistance; affective disorders; transcranial magnetic stimulation; stimulation intensity; current density; dorsolateral prefrontal cortex
 Abstract: Repetitive transcranial magnetic stimulation (rTMS) has been found to exert modest to substantial antidepressant effects in the majority of prior clinical studies. As effect sizes and stimulation conditions have varied greatly, controversy persists regarding effective stimulation parameters (e.g. intensity, frequcncy, localization). In the present controlled study, we investigated whether the antidepressant efficacy of rTMS may be related to the stimulation intensity applied. Thirty-one patients suffering from a pharmacotherapy-resistant major depressive episode were randomly assigned to three treatment groups receiving rTMS at different stimulation intensities: (1) intensity at the individual motor threshold (MT); (2) 90% subthreshold intensity; and (3) low intensity of standard sham rTMS. Each patient underwent 10 sessions of 10 Hz rTMS with 1500 stimuli/day over the left dorsolateral prefrontal cortex. Improvement of depressive symptoms after rTMS significantly increased with stimulation intensity across the three groups. A 30% to 33% reduction of baseline depression scores was observed after rTMS at MT intensity. Similarly, groups differed significantly regarding the clinical course after rTMS with the lowest number of antidepressant interventions and the shortest hospital stay in the MT intensity group. These findings support the hypothesis of a relationship between stimulation intensity of rTMS and its antidepressant efficac

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Language(s): eng - English
 Dates: 2002-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4091
ISI: 000177983700013
 Degree: -

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Title: Neuropsychopharmacology
  Alternative Title : Neuropsychopharmacology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 27 (4) Sequence Number: - Start / End Page: 638 - 645 Identifier: ISSN: 0893-133X