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  Repetitive transcranial magnetic stimulation (rTMS) in major depression: Relation between efficacy and stimulation intensity

Padberg, F., Zwanzger, P., Keck, M., Kathmann, N., Mikhaiel, P., Ella, R., et al. (2002). Repetitive transcranial magnetic stimulation (rTMS) in major depression: Relation between efficacy and stimulation intensity. Neuropsychopharmacology, 27(4), 638-645.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A14B-9 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A14C-7
Genre: Zeitschriftenartikel
Alternativer Titel : Neuropsychopharmacology

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 Urheber:
Padberg, F1, Autor
Zwanzger, P1, Autor
Keck, ME1, Autor
Kathmann, N1, Autor
Mikhaiel, P1, Autor
Ella, R1, Autor
Rupprecht, P1, Autor
Thoma, H1, Autor
Hampel, H1, Autor
Toschi, N1, Autor
Möller, HJ1, Autor
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Schlagwörter: major depression; medication resistance; affective disorders; transcranial magnetic stimulation; stimulation intensity; current density; dorsolateral prefrontal cortex
 Zusammenfassung: Repetitive transcranial magnetic stimulation (rTMS) has been found to exert modest to substantial antidepressant effects in the majority of prior clinical studies. As effect sizes and stimulation conditions have varied greatly, controversy persists regarding effective stimulation parameters (e.g. intensity, frequcncy, localization). In the present controlled study, we investigated whether the antidepressant efficacy of rTMS may be related to the stimulation intensity applied. Thirty-one patients suffering from a pharmacotherapy-resistant major depressive episode were randomly assigned to three treatment groups receiving rTMS at different stimulation intensities: (1) intensity at the individual motor threshold (MT); (2) 90% subthreshold intensity; and (3) low intensity of standard sham rTMS. Each patient underwent 10 sessions of 10 Hz rTMS with 1500 stimuli/day over the left dorsolateral prefrontal cortex. Improvement of depressive symptoms after rTMS significantly increased with stimulation intensity across the three groups. A 30% to 33% reduction of baseline depression scores was observed after rTMS at MT intensity. Similarly, groups differed significantly regarding the clinical course after rTMS with the lowest number of antidepressant interventions and the shortest hospital stay in the MT intensity group. These findings support the hypothesis of a relationship between stimulation intensity of rTMS and its antidepressant efficac

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Sprache(n): eng - English
 Datum: 2002-10
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 4091
ISI: 000177983700013
 Art des Abschluß: -

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Titel: Neuropsychopharmacology
  Alternativer Titel : Neuropsychopharmacology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 27 (4) Artikelnummer: - Start- / Endseite: 638 - 645 Identifikator: ISSN: 0893-133X