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  Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice

Refojo, D., Kovalovsky, D., Young, J., Rubinstein, M., Holsboer, F., Reul, J., et al. (2002). Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice. Journal of Neuroimmunology, 131(1-2), 126-134.

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Genre: Zeitschriftenartikel
Alternativer Titel : J. Neuroimmunol.

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 Urheber:
Refojo, D1, Autor
Kovalovsky, D1, Autor
Young, JI1, Autor
Rubinstein, M1, Autor
Holsboer, F1, Autor
Reul, JMHM1, Autor
Low, MJ1, Autor
Arzt, E1, Autor
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Schlagwörter: beta-endorphin; splenocyte; cytokines; HPA axis; neuroimmunology
 Zusammenfassung: We used beta-endorphin-deficient mice as a novel approach to confirm the physiological role that opioid peptides play in the development or regulation of the immune system. We found that mice lacking beta-endorphin possessed an enhanced immune response, measured in terms of splenocyte proliferation and interleukin (IL)-2 mRNA levels, in vitro production of the splenic macrophage inflammatory cytokines IL-6 and Tumor Necrosis Factor (TNF)-alpha and plasma IL-6 following lipopolysaccharide (LPS) administration. beta-Endorphin- deficient mice had attenuated increases of plasma ACTH and corticosterone levels in response to LPS. These results are consistent with a postulated inhibitory role of endogenous beta-endorphin on the immune system at multiple levels. (C) 2002 Elsevier Science B.V. All rights reserve

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Sprache(n): eng - English
 Datum: 2002-10
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 4054
ISI: 000178791600013
 Art des Abschluß: -

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Titel: Journal of Neuroimmunology
  Alternativer Titel : J. Neuroimmunol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 131 (1-2) Artikelnummer: - Start- / Endseite: 126 - 134 Identifikator: ISSN: 0165-5728