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  Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice

Refojo, D., Kovalovsky, D., Young, J., Rubinstein, M., Holsboer, F., Reul, J., et al. (2002). Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice. Journal of Neuroimmunology, 131(1-2), 126-134.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A145-6 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A146-4
Genre: Journal Article
Alternative Title : J. Neuroimmunol.

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 Creators:
Refojo, D1, Author
Kovalovsky, D1, Author
Young, JI1, Author
Rubinstein, M1, Author
Holsboer, F1, Author
Reul, JMHM1, Author
Low, MJ1, Author
Arzt, E1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: beta-endorphin; splenocyte; cytokines; HPA axis; neuroimmunology
 Abstract: We used beta-endorphin-deficient mice as a novel approach to confirm the physiological role that opioid peptides play in the development or regulation of the immune system. We found that mice lacking beta-endorphin possessed an enhanced immune response, measured in terms of splenocyte proliferation and interleukin (IL)-2 mRNA levels, in vitro production of the splenic macrophage inflammatory cytokines IL-6 and Tumor Necrosis Factor (TNF)-alpha and plasma IL-6 following lipopolysaccharide (LPS) administration. beta-Endorphin- deficient mice had attenuated increases of plasma ACTH and corticosterone levels in response to LPS. These results are consistent with a postulated inhibitory role of endogenous beta-endorphin on the immune system at multiple levels. (C) 2002 Elsevier Science B.V. All rights reserve

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Language(s): eng - English
 Dates: 2002-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4054
ISI: 000178791600013
 Degree: -

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Title: Journal of Neuroimmunology
  Alternative Title : J. Neuroimmunol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 131 (1-2) Sequence Number: - Start / End Page: 126 - 134 Identifier: ISSN: 0165-5728