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  Cushing's syndrome: drug targets and therapeutic options

Paez-Pereda, M., Arzt, E., & Stalla, G. (2002). Cushing's syndrome: drug targets and therapeutic options. Expert Opinion on Therapeutic Patents, 12(10), 1537-1546.

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Genre: Journal Article
Alternative Title : Expert Opin. Ther. Patents

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 Creators:
Paez-Pereda, M1, Author
Arzt, E1, Author
Stalla, GK1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: adrenocorticotrophic hormone (ACTH); Cushing''s syndrome; glucocorticoids; hypothalamus-pituitary adrenal (HPA) axis; pro-opiomelanocortin (POMC
 Abstract: Cushing''s syndrome is caused by endocrine and metabolic alterations produced by high levels of glucocorticoids. Glucocorticoid excess is usually a result of exogenous administration of glucocorticoids or alteration of the hypothalamus-pituitary-adrenal (HPA) axis. However, in the majority of patients it is due to an adrenocorticotrophic hormone (ACTH)-secreting pituitary adenoma. Other possible causes are ectopic ACTH-secreting tumours of the lung, glucocorticoid-producing adrenal tumours and other ectopic tumours. The symptoms include central fat deposition, altered energy and protein metabolism, hypertension and depression. The molecular mechanisms that regulate the HPA axis provide a rationale to correct the alterations observed in Cushing''s syndrome. Recent developments have identified possible targets and drugs for therapy at different levels of the HPA axis. This article reviews patents claiming novel targets and drugs for Cushing''s syndrome in the period 1997-200

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Language(s): eng - English
 Dates: 2002-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4060
ISI: 000178580900006
 Degree: -

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Title: Expert Opinion on Therapeutic Patents
  Alternative Title : Expert Opin. Ther. Patents
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 12 (10) Sequence Number: - Start / End Page: 1537 - 1546 Identifier: ISSN: 1354-3776