English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis

Salome, N., Viltart, O., Darnaudery, M., Salchner, P., Singewald, N., Landgraf, R., et al. (2002). Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis. Behavioural Brain Research, 136(1), 227-237.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Behav. Brain Res.

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Salome, N1, Author
Viltart, O1, Author
Darnaudery, M1, Author
Salchner, P1, Author
Singewald, N1, Author
Landgraf, R1, Author
Sequeira, H1, Author
Wigger, A1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

Content

show
hide
Free keywords: elevated plus-maze test; black-white box test; forced swim test; principal component analysis; HAB rats
 Abstract: The reliability of behavioural data constitutes a major concern in the neuroscience field. Indeed, discrepancies in the behavioural patterns of mice or rats in the same anxiety tests performed in different laboratories have been reported recently. The question raised by such data addressed, in particular, the selection and breeding of two lines of rats on the basis of their high (HAB) and low (LAB) anxiety-related behaviour in the elevated plus-maze test at the Max Planck Institute of Psychiatry in Munich (Germany). As the majority of the behavioural data in these animals has been derived from research carried out in this institute, the aims of the present study were: (1) to test the reliability of the differences in anxiety-related behaviour of these rats in two other laboratories (Villeneuve d''Ascq, France and Innsbruck, Austria); and (2) to determine how the different behavioural traits were associated in both HAB and LAB rats by a principal component analysis. Results were in agreement with the studies performed in Munich, as the divergence in anxiety-related behaviour of the two lines was highly consistent in all tests performed in Villeneuve d''Ascq and Innsbruck. Moreover, the most important parameters to discriminate the two lines were similar to those found in a previous study. Finally, the principal component analysis again confirmed that the selection of HAB and LAB rats is based on anxiety-related behaviour rather than locomotor activity. (C) 2002 Elsevier Science B.V. All rights reserve

Details

show
hide
Language(s): eng - English
 Dates: 2002-10-17
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4052
ISI: 000178776300025
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Behavioural Brain Research
  Alternative Title : Behav. Brain Res.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 136 (1) Sequence Number: - Start / End Page: 227 - 237 Identifier: ISSN: 0166-4328