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  Plasma concentrations of neuroactive steroids before and after repetitive transcranial magnetic stimulation (rTMS) in major depression

Padberg, F., di Michele, F., Zwanzger, P., Romeo, E., Bernardi, G., Schule, C., et al. (2002). Plasma concentrations of neuroactive steroids before and after repetitive transcranial magnetic stimulation (rTMS) in major depression. Neuropsychopharmacology, 27(5), 874-878.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A021-D Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A022-B
Genre: Journal Article
Alternative Title : Neuropsychopharmacology

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 Creators:
Padberg, FA1, Author
di Michele, F1, Author
Zwanzger, P1, Author
Romeo, E1, Author
Bernardi, G1, Author
Schule, C1, Author
Baghai, TC1, Author
Ella, R1, Author
Pasini, A1, Author
Rupprecht, R1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: affective disorders; antidepressant treatment; neuroactive steroids; prefrontal cortex; transcranial magnetic stimulation; TMS
 Abstract: There is evidence for altered levels of neuroactive steroids in major depression that normalize after successful antidepressant pharmacotherapy. Currently it is not known whether this is a general principle of clinically effective antidepressant therapy or a pharmacological effect of antidepressants. Here, we investigated whether repetitive transcranial magnetic stimulation (rTMS) may affect plasma concentrations of neuroactive steroids in a similar way as antidepressant pharmacotherapy. Progesterone, 3alpha, 5alpha- tetrahydroprogesterone (3alpha, 5alpha-THP), 3alpha, 5beta- tetrahydroprogesterone (3alpha ,5beta-THP), 3beta, 5alpha- tetrahydroprogesterone (3beta, 5alpha-THP) and dehydroepiandrosterone (DHEA) were quantified in 37 medication- free patients sufferingfrom a major depressive episode before and after 10 sessions of left prefrontal rTMS. Plasma samples were analyzed by means of a highly sensitive and specific combined gas chromatography/mass spectrometry analysis. There was a significant reduction of depressive symptoms after rTMS. However, plasma concentrations of neuroactive steroids were not affected by rTMS and not related to clinical response. Clinical improvement after extended daily treatment with rTMS is not accompanied by changes in neuroactivc steroid levels. Changes in neuroactive steroid levels after antidepressant pharmacotherapy more likely reflect specific pharmacological effects of antidepressant drugs and are not necessary for the amelioration of depressive symptoms. (C) 2002 American College of Neuropsychopharmacology. Published by Elsevier Science In

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Language(s): eng - English
 Dates: 2002-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4057
ISI: 000178600100019
 Degree: -

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Title: Neuropsychopharmacology
  Alternative Title : Neuropsychopharmacology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 27 (5) Sequence Number: - Start / End Page: 874 - 878 Identifier: ISSN: 0893-133X