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  Mineralocorticoid receptor function in patients with posttraumatic stress disorder

Kellner, M., Baker, D., Yassouridis, A., Bettinger, S., Otte, C., Naber, D., et al. (2002). Mineralocorticoid receptor function in patients with posttraumatic stress disorder. American Journal of Psychiatry, 159(11), 1938-1940.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A01F-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A020-F
Genre: Journal Article
Alternative Title : Am. J. Psychiat.

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 Creators:
Kellner, M1, Author
Baker, DG1, Author
Yassouridis, A1, Author
Bettinger, S1, Author
Otte, C1, Author
Naber, D1, Author
Wiedemann, K1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Abstract: Objective: The study examined whether enhanced limbic mineralocorticoid receptor activity resulting in negative glucocorticoid feedback could contribute to the diminished basal and stress-induced cortisol output reported in patients with post-traumatic stress disorder (PTSD). Method: The effects of acute antimineralocorticoid (spironolactone) versus placebo pretreatment on levels of plasma cortisol at baseline and after stimulations with corticotropin-releasing hormone (CRH) and on adrenocorticotropic hormone (ACTH) level were measured in 12 PTSD patients and 12 healthy comparison subjects, Results: Spironolactone significantly elevated basal cortisol and ACTH concentrations as well as cortisol secretion after CRH stimulation, but no differential effect between PTSD patients and comparison subjects was detected. Conclusions: The results indicate intact, but not enhanced, mineralocorticoid receptor function in PTSD. The study''s experimental conditions did not allow determination of whether other compensatory factors might have masked the putative mineralocorticoid receptor change

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Language(s): eng - English
 Dates: 2002-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4043
ISI: 000179120300025
 Degree: -

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Title: American Journal of Psychiatry
  Alternative Title : Am. J. Psychiat.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 159 (11) Sequence Number: - Start / End Page: 1938 - 1940 Identifier: ISSN: 0002-953X