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  Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion

Reichenberg, A., Kraus, T., Haack, M., Schuld, A., Pollmächer, T., & Yirmiya, R. (2002). Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion. Psychoneuroendocrinology, 27(8), 945-956.

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Genre: Zeitschriftenartikel
Alternativer Titel : Psychoneuroendocrinology

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 Urheber:
Reichenberg, A1, Autor
Kraus, T1, Autor
Haack, M1, Autor
Schuld, A1, Autor
Pollmächer, T1, Autor
Yirmiya, R1, Autor
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Schlagwörter: endotoxin; cytokines; anorexia; food consumption
 Zusammenfassung: This study examined the effects of endotoxin administration on food and water consumption in humans, and the associations between these changes and endotoxin-induced secretion of cytokines, cortisol, and fever. Twenty healthy male volunteers received an i.v. injection of Salmonella abortus equi endotoxin (0.8 ng/kg) or saline in two experimental sessions. Blood samples were collected hourly, and rectal temperature was monitored continuously. Food consumption was significantly reduced at 0-4 h and significantly elevated at 4-5 h after the endotoxin injection. Endotoxin administration had no significant effect on water consumption. Endotoxin-induced secretion of TNF-alpha and IL-6 was positively associated with the decrease in food consumption (r = 0.61 and 0.68), and negatively associated with the rebound increase in food consumption (r = -0.53 and -0.45). Neither the febrile response, nor the secretion of cortisol was associated with the changes in food consumption. These results suggest that TNF- alpha and IL-6 are involved in endotoxin-induced anorexia in humans. (C) 2002 Elsevier Science Ltd. All rights reserve

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Sprache(n): eng - English
 Datum: 2002-11
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 4034
ISI: 000179600500006
 Art des Abschluß: -

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Titel: Psychoneuroendocrinology
  Alternativer Titel : Psychoneuroendocrinology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 27 (8) Artikelnummer: - Start- / Endseite: 945 - 956 Identifikator: ISSN: 0306-4530