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  Miswiring of limbic thalamocortical projections in the absence of ephrin-A5

Uziel, D., Mühlfriedel, S., Zarbalis, K., Wurst, W., Levitt, P., & Bolz, J. (2002). Miswiring of limbic thalamocortical projections in the absence of ephrin-A5. Journal of Neuroscience, 22(21), 9352-9357.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A011-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A012-D
Genre: Journal Article
Alternative Title : J. Neurosci.

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 Creators:
Uziel, D1, Author
Mühlfriedel, S1, Author
Zarbalis, K1, Author
Wurst, W1, Author
Levitt, P1, Author
Bolz, J1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: wiring molecules; axonal guidance; cortical development; limbic system; thalamocortical circuits; ephrin
 Abstract: Axon guidance cues of the ephrin ligand family have been hypothesized to regulate the formation of thalamocortical connections, but in vivo evidence for such a role has not been examined directly. To test whether ephrin-mediated repulsive cues participate in sorting the projections originating from distinct thalamic nuclei, we analyzed the organization of somatosensory and anterior cingulate afferents postnatally in mice lacking ephrin-A5 gene expression. Projections from ventrobasal and laterodorsal nuclei to their respective sensory and limbic cortical areas developed normally. However, a portion of limbic thalamic neurons from the laterodorsal nucleus also formed additional projections to somatosensory cortical territories, thus maintaining inappropriate dual projections to multiple cortical regions. These results suggest that ephrin-A5 is not required for the formation of normal cortical projections from the appropriate thalamic nuclei, but rather acts as a guidance cue that restricts limbic thalamic axons from inappropriate neocortical region

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Language(s): eng - English
 Dates: 2002-11-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4041
ISI: 000179031600025
 Degree: -

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Title: Journal of Neuroscience
  Alternative Title : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 22 (21) Sequence Number: - Start / End Page: 9352 - 9357 Identifier: ISSN: 0270-6474