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  Modulation of cytokine mRNA expression by brain-derived neurotrophic factor and nerve growth factor in human immune cells

Bayas, A., Kruse, N., Moriabadi, N., Weber, F., Hummel, V., Wohleben, G., et al. (2003). Modulation of cytokine mRNA expression by brain-derived neurotrophic factor and nerve growth factor in human immune cells. Neuroscience Letters, 335(3), 155-158.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-9F55-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-9F56-D
Genre: Journal Article
Alternative Title : Neurosci. Lett.

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 Creators:
Bayas, A, Author
Kruse, N, Author
Moriabadi, NF, Author
Weber, F1, Author
Hummel, V, Author
Wohleben, G, Author
Gold, R, Author
Toyka, KV, Author
Rieckmann, P, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: brain-derived neurotrophic factor; nerve growth factor; cytokine mRNA; human; immune cells
 Abstract: Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) exert various effects on immune cells. Here we studied, whether they influence the cytokine expression pattern in peripheral blood mononuclear cells (PBMCs) or antigen specific T-cells. In PBMCs BDNF and NGF had interindividually variable effects on T helper cell type (Th)1- and Th2- cytokines. However, there was a high correlation between the modulating properties of these neurotrophins (r = 0.97) concerning the expression of interleukin (IL) 4, transforming growth factor-beta and tumour necrosis factor-alpha mRNA at a concentration of 100 ng/ml. In myelin basic protein-specific T- cell lines BDNF and NGF increased interferon -gamma mRNA to a moderate extent, but not IL4. No major effects were detected at the cytokine protein level. In conclusion, our results suggest a partial effect of neurotrophins on immune cells, which may be modified by other signals. (C) 2002 Elsevier Science Ireland Ltd. All rights reserve

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Language(s): eng - English
 Dates: 2003-01-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4014
ISI: 000180410900002
 Degree: -

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Title: Neuroscience Letters
  Alternative Title : Neurosci. Lett.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 335 (3) Sequence Number: - Start / End Page: 155 - 158 Identifier: ISSN: 0304-3940