Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 Lokale TagsFreigabegeschichteDetailsÜbersicht
  Modulation of cytokine mRNA expression by brain-derived neurotrophic factor and nerve growth factor in human immune cells

Bayas, A., Kruse, N., Moriabadi, N., Weber, F., Hummel, V., Wohleben, G., et al. (2003). Modulation of cytokine mRNA expression by brain-derived neurotrophic factor and nerve growth factor in human immune cells. Neuroscience Letters, 335(3), 155-158.

Item is

 

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:
Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-9F55-F Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-9F56-D
Genre: Zeitschriftenartikel
Alternativer Titel : Neurosci. Lett.

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Bayas, A, Autor
Kruse, N, Autor
Moriabadi, NF, Autor
Weber, F1, Autor
Hummel, V, Autor
Wohleben, G, Autor
Gold, R, Autor
Toyka, KV, Autor
Rieckmann, P, Autor
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

Inhalt

einblenden:
ausblenden:
Schlagwörter: brain-derived neurotrophic factor; nerve growth factor; cytokine mRNA; human; immune cells
 Zusammenfassung: Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) exert various effects on immune cells. Here we studied, whether they influence the cytokine expression pattern in peripheral blood mononuclear cells (PBMCs) or antigen specific T-cells. In PBMCs BDNF and NGF had interindividually variable effects on T helper cell type (Th)1- and Th2- cytokines. However, there was a high correlation between the modulating properties of these neurotrophins (r = 0.97) concerning the expression of interleukin (IL) 4, transforming growth factor-beta and tumour necrosis factor-alpha mRNA at a concentration of 100 ng/ml. In myelin basic protein-specific T- cell lines BDNF and NGF increased interferon -gamma mRNA to a moderate extent, but not IL4. No major effects were detected at the cytokine protein level. In conclusion, our results suggest a partial effect of neurotrophins on immune cells, which may be modified by other signals. (C) 2002 Elsevier Science Ireland Ltd. All rights reserve

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2003-01-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 4014
ISI: 000180410900002
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Neuroscience Letters
  Alternativer Titel : Neurosci. Lett.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 335 (3) Artikelnummer: - Start- / Endseite: 155 - 158 Identifikator: ISSN: 0304-3940