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  The effect of acetylcholinesterase-inhibition on depolarization-induced GABA release from rat striatal slices

Grasshoff, C., Gillessen, T., Thiermann, H., Wagner, E., & Szinicz, L. (2003). The effect of acetylcholinesterase-inhibition on depolarization-induced GABA release from rat striatal slices. Toxicology, 184(2-3), 149-156.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-9F1B-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-9F1C-2
Genre: Journal Article
Alternative Title : Toxicology

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 Creators:
Grasshoff, C, Author
Gillessen, T1, Author
Thiermann, H, Author
Wagner, E, Author
Szinicz, L, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: acetylcholinesterase-inhibition; GABA; M-cholinoceptors; neostigmine; soman (pinacolyl methylphosphonofluoridate); striatum
 Abstract: The severity of poisoning after intoxication with the acetylcholinesterase (AChE) inhibitor soman has been shown to be positively correlated with GABA release in rat striatum. Since most of the neurons in striatum and striatal projection regions use GABA as transmitter, it is still unclear, whether an increase of extracellular GABA in this region results from enhanced activation of these projections or is due to the local effect of AChE inhibition. In this study, the modulation of depolarization-induced increase in GABA concentration by soman was determined in the superfusate of rat striatal slices. Soman and neostigmine increased GABA concentration in the superfusate dose dependently. This increase was exerted through M- cholinoceptors as it could be blocked by atropine and enhanced by application of the muscarinic agonists pilocarpine or oxotremorine. These results clearly indicate that AChE inhibition by soman in rat striatum can directly lead to enhanced release of GABA through M-cholinoceptors. (C) 2002 Elsevier Science Ireland Ltd. All rights reserve

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Language(s): eng - English
 Dates: 2003-03-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 3992
ISI: 000180972900007
 Degree: -

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Title: Toxicology
  Alternative Title : Toxicology
Source Genre: Journal
 Creator(s):
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Publ. Info: -
Pages: - Volume / Issue: 184 (2-3) Sequence Number: - Start / End Page: 149 - 156 Identifier: ISSN: 0300-483X