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  Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder

Ströhle, A., Scheel, M., Modell, S., & Holsboer, F. (2008). Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder. Journal of Psychiatric Research, 42(14), 1185-1188.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-93C3-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-93C4-6
Genre: Journal Article
Alternative Title : J. Psychiatr. Res.

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 Creators:
Ströhle, A., Author
Scheel, M., Author
Modell, S.1, Author           
Holsboer, F.2, Author           
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
2Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607139              

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Free keywords: Posttraumatic stress disorder; ACTH; Cortisol; Dexamethasone; Corticotropin releasing hormone
 Abstract: Previous studies have suggested that patients with posttraumatic stress disorder (PTSD) have an enhanced negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) system and a blunted ACTH response to corticotropin releasing hormone (CRH). The effects of two dexamethasone dosages (0.75 and 1.5 mg) on the ACTH and cortisol concentrations after CRH stimulation (100 mu g) were studied in eight patients with PTSD and matched healthy control subjects. Compared to healthy subjects, patients with PTSD have a blunted ACTH response to CRH. Cortisol concentrations were only significantly influenced by dexamethasone dosage. Our results give further evidence for a central role of the pituitary in reflecting changes of the negative feedback sensitivity of the HPA system in patients with PTSD. (C) 2008 Elsevier Ltd. All rights reserved.

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Language(s): eng - English
 Dates: 2008-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 395633
ISI: 000260666200006
 Degree: -

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Title: Journal of Psychiatric Research
  Alternative Title : J. Psychiatr. Res.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 42 (14) Sequence Number: - Start / End Page: 1185 - 1188 Identifier: ISSN: 0022-3956