English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Combined Effects of Exonic Polymorphisms in CRHR1 and AVPR1B Genes in a Case/Control Study for Panic Disorder

Keck, M. E., Kern, N., Erhardt, A., Unschuld, P. G., Ising, M., Salyakina, D., et al. (2008). Combined Effects of Exonic Polymorphisms in CRHR1 and AVPR1B Genes in a Case/Control Study for Panic Disorder. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147B(7), 1196-1204.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Am. J. Med. Genet. B

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Keck, M. E.1, Author           
Kern, N.1, Author           
Erhardt, A.2, Author           
Unschuld, P. G.2, Author           
Ising, M.3, Author           
Salyakina, D., Author
Müller, M. B.4, Author           
Knorr, C. C., Author
Lieb, R.1, Author           
Hohoff, C., Author
Krakowitzky, P., Author
Maier, W., Author
Bandelow, B., Author
Fritze, J., Author
Deckert, J., Author
Holsboer, F.5, Author           
Müller-Myhsok, B.6, Author           
Binder, E. B.2, Author           
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
2AG Binder, Elisabeth, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607142              
3AG Ising, Marcus, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607149              
4AG Müller, Marianne, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607153              
5Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607139              
6AG Müller-Myhsok, Bertram, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607154              

Content

show
hide
Free keywords: anxiety disorders; association; SNP; CRHR1; AVPR1B
 Abstract: Accumulating evidence from animal studies suggests that the corticotropin releasing hormone (CRH) and arginine vasopressin (AVP) neuropeptide systems, contribute to anxiety behavior. To investigate whether polymorphisms in the genes regulating these two systems may alter susceptibility to anxiety disorders in humans, we genotyped 71 single nucleotide polymorphisms (SNPs) in CRH, CRHR1, CRHR2, AVP, AVPR1A, AVPR1B in a German sample from Munich with patients suffering from panic disorder and matched healthy controls (n = 186/n = 299). Significant associations were then replicated in a second German sample with 173 patients with panic disorder and 495 controls. In both samples separately and the combined sample, SNPs within CHRH1 and AVPR1B were nominally associated with panic disorder. We then tested two locus multiplicative and interaction effects of polymorphisms of these two genes on panic disorder. Fifteen SNP pairs showed significant multiplicative effects in both samples. The SNP pair with the most significant association in the combined sample (P = 0.00057), which withstood correction for multiple testing, was rs878886 in CRHR1 and rs28632197 in AVPR1B. Both SNPs are of potential functional relevance as rs878886 is located in the 3' untranslated region of the CRHR1 and rs28632197 leads to an arginine to histidine amino acid exchange at position 364 of AVPR1B which is located in the intracellular C-terminal domain of the receptor. These data suggest that polymorphisms in the AVPR1B and the CRHR1 genes alter the susceptibility to panic disorder. (C) 2008 Wiley-Liss, Inc.

Details

show
hide
Language(s): eng - English
 Dates: 2008-10-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 395624
ISI: 000259979500026
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
  Alternative Title : Am. J. Med. Genet. B
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 147B (7) Sequence Number: - Start / End Page: 1196 - 1204 Identifier: ISSN: 1552-4841