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  TRANSGENIC OVEREXPRESSION OF CORTICOTROPIN RELEASING HORMONE PROVIDES PARTIAL PROTECTION AGAINST NEURODEGENERATION IN AN IN VIVO MODEL OF ACUTE EXCITOTOXIC STRESS

Hanstein, R., Lu, A., Wurst, W., Holsboer, F., Deussing, J. M., Clement, A. B., et al. (2008). TRANSGENIC OVEREXPRESSION OF CORTICOTROPIN RELEASING HORMONE PROVIDES PARTIAL PROTECTION AGAINST NEURODEGENERATION IN AN IN VIVO MODEL OF ACUTE EXCITOTOXIC STRESS. Neuroscience, 156(3), 712-721.

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Hanstein, R., Autor
Lu, A.1, Autor           
Wurst, W.2, Autor           
Holsboer, F.3, Autor           
Deussing, J. M.4, Autor           
Clement, A. B., Autor
Behl, C.2, Autor           
Affiliations:
1AG Almeida, Osborne, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607141              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
3Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607139              
4AG Deussing, Jan, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607145              

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Schlagwörter: CRH; BDNF; excitotoxicity; neuroprotection
 Zusammenfassung: Corticotropin releasing hormone (CRH) is the central modulator of the mammalian hypothalamic-pituitaryadrenal (HPA) axis. In addition, CRH affects other processes in the brain including learning, memory, and synaptic plasticity. Moreover, CRH has been shown to play a role in nerve cell survival under apoptotic conditions and to serve as an endogenous neuroprotectant in vitro. Employing mice over-expressing murine CRH in the CNS, we observed a differential response of CRH-overexpressing mice (CRH-COEhom-Nes) to acute excitotoxic stress induced by kainate compared with controls (CRH-COEcon-Nes). Interestingly, CRH-overexpression reduced the duration of epileptic seizures and prevented kainate-induced neurodegeneration and neuro-inflammation in the hippocampus. Our findings highlight a neuroprotective action of CRH in vivo. This neuroprotective effect was accompanied by increased levels of brain-derived neurotrophic factor (BDNF) in CRH-COEhom-Nes mice, suggesting a potential role for BDNF in mediating CRH-induced neuroprotective actions against acute excitotoxicity in vivo. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.

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Sprache(n): eng - English
 Datum: 2008-10-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 395621
ISI: 000260508100027
 Art des Abschluß: -

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Titel: Neuroscience
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 156 (3) Artikelnummer: - Start- / Endseite: 712 - 721 Identifikator: ISSN: 0306-4522