Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway

Labeur, M., Refojo, D., Wölfel, B., Stalla, J., Vargas, V., Theodoropoulou, M., et al. (2008). Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway. Journal of Endocrinology, 199(2), 177-189.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel
Alternativer Titel : J. Endocrinol.

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Labeur, M.1, Autor           
Refojo, D.2, Autor           
Wölfel, B.1, Autor           
Stalla, J.1, Autor           
Vargas, V.3, Autor           
Theodoropoulou, M.1, Autor           
Buchfelder, M., Autor
Paez-Pereda, M.1, Autor           
Arzt, E.3, Autor           
Stalla, G. K.3, Autor
Affiliations:
1AG Stalla, Günter, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607159              
2AG Deussing, Jan, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607145              
3Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Interferon-gamma (IFNG) is a cytokine that exerts potent antiproliferative and tumoricidal effects in a variety of cancers. Moreover, IFNG modulates normal pituitary hormone secretion, and was shown to inhibit the expression of the ACTH precursor POMC in murine ACTH-secreting AtT-20 tumor cells. We have studied the functional role of IFNG on pituitary tumor cells, focusing on the involvement of IFNG in the molecular events leading to the control of POMC transcriptional repression. Herein, it is shown that IFNG inhibits AtT-20 tumor cell proliferation without inducing apoptosis. Unexpectedly, an activated janus kinases-signal transducer and activator of transcription (JAK-STAT1) cascade is required for IFNG inhibitory action on POW promoter activity. Factor-kappa B (NF-kappa B) is necessary for the inhibitory action of IFNG on Pomc transcription, since loss of NF-kappa B activity with I kappa B super-repressor abolishes this effect. In addition, 1 and 2 IFNG receptor immunoreactivity was detected in human corticotropinoma cells. Interestingly, IFNG inhibits ACTH production from these cells in primary cell culture, Without affecting basal ACTH biosynthesis in normal non-tumoral pituitary cells. In conclusion, our data show for the first time that POMC transcription can be negatively regulated by a JAK-STAT1 and NF-kappa B-depenclent pathway.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2008-11
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 395625
ISI: 000260768600004
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Journal of Endocrinology
  Alternativer Titel : J. Endocrinol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 199 (2) Artikelnummer: - Start- / Endseite: 177 - 189 Identifikator: ISSN: 0022-0795