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  Gene Expression Studies in Major Depression

Mehta, D., Menke, A., & Binder, E. B. (2010). Gene Expression Studies in Major Depression. Current Psychiatry Reports, 12(2), 135-144.

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 Urheber:
Mehta, D.1, Autor           
Menke, A.1, Autor           
Binder, E. B.1, Autor           
Affiliations:
1AG Binder, Elisabeth, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607142              

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 Zusammenfassung: The dramatic technical advances in methods to measure gene expression on a genome-wide level thus far have not been paralleled by breakthrough discoveries in psychiatric disorders-including major depression (MD)-using these hypothesis-free approaches. In this review, we first describe the methodologic advances made in gene expression analysis, from quantitative polymerase chain reaction to next-generation sequencing. We then discuss issues in gene expression experiments specific to MD, ranging from the choice of target tissues to the characterization of the case group. We provide a synopsis of the gene expression studies published thus far for MD, with a focus on studies using mRNA microarray methods. Finally, we discuss possible new strategies for the gene expression studies in MD that circumvent some of the addressed issues.

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Sprache(n): eng - English
 Datum: 2010-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 563624
ISI: 000289731200010
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Titel: Current Psychiatry Reports
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 12 (2) Artikelnummer: - Start- / Endseite: 135 - 144 Identifikator: ISSN: 1523-3812