Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments

Pham, T. T., Giesert, F., Rothig, A., Floss, T., Kallnik, M., Weindl, K., et al. (2010). DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments. Genes Brain and Behavior, 9(3), 305-317.

Item is

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Pham, T. T., Autor
Giesert, F., Autor
Rothig, A., Autor
Floss, T., Autor
Kallnik, M., Autor
Weindl, K., Autor
Hölter, S. M.1, Autor           
Ahting, U., Autor
Prokisch, H., Autor
Becker, L., Autor
Klopstock, T., Autor
de Angelis, M. H., Autor
Beyer, K., Autor
Görner, K., Autor
Kahle, P. J., Autor
Vogt-Weisenhorn, D. M.2, Autor           
Wurst, W.1, Autor           
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
2AG Deussing, Jan, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607145              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Loss of function of DJ-1 (PARK7) is associated with autosomal recessive early-onset Parkinson's disease (PD), one of the major age-related neurological diseases. In this study, we extended former studies on DJ-1 knockout mice by identifying subtle morphological and behavioural phenotypes. The DJ-1 gene trap-induced null mutants exhibit less dopamine-producing neurons in the ventral tegmental area (VTA). They also exhibit slight changes in behaviour, i.e. diminished rearing behaviour and impairments in object recognition. Furthermore, we detected subtle phenotypes, which suggest that these animals compensate for the loss of DJ-1. First, we found a significant upregulation of mitochondrial respiratory enzyme activities, a mechanism known to protect against oxidative stress. Second, a close to significant increase in c-Jun N-terminal kinase 1 phosphorylation in old DJ-1-deficient mice hints at a differential activation of neuronal cell survival pathways. Third, as no change in the density of tyrosine hydroxylase (TH)-positive terminals in the striatum was observed, the remaining dopamine-producing neurons likely compensate by increasing axonal sprouting. In summary, the present data suggest that DJ-1 is implicated in major non-motor symptoms of PD appearing in the early phases of the disease-such as subtle impairments in motivated behaviour and cognition-and that under basal conditions the loss of DJ-1 is compensated.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2010-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 475610
ISI: 000276604800006
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Genes Brain and Behavior
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 9 (3) Artikelnummer: - Start- / Endseite: 305 - 317 Identifikator: ISSN: 1601-1848