English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments

Pham, T. T., Giesert, F., Rothig, A., Floss, T., Kallnik, M., Weindl, K., et al. (2010). DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments. Genes Brain and Behavior, 9(3), 305-317.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Pham, T. T., Author
Giesert, F., Author
Rothig, A., Author
Floss, T., Author
Kallnik, M., Author
Weindl, K., Author
Hölter, S. M.1, Author           
Ahting, U., Author
Prokisch, H., Author
Becker, L., Author
Klopstock, T., Author
de Angelis, M. H., Author
Beyer, K., Author
Görner, K., Author
Kahle, P. J., Author
Vogt-Weisenhorn, D. M.2, Author           
Wurst, W.1, Author           
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
2AG Deussing, Jan, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607145              

Content

show
hide
Free keywords: -
 Abstract: Loss of function of DJ-1 (PARK7) is associated with autosomal recessive early-onset Parkinson's disease (PD), one of the major age-related neurological diseases. In this study, we extended former studies on DJ-1 knockout mice by identifying subtle morphological and behavioural phenotypes. The DJ-1 gene trap-induced null mutants exhibit less dopamine-producing neurons in the ventral tegmental area (VTA). They also exhibit slight changes in behaviour, i.e. diminished rearing behaviour and impairments in object recognition. Furthermore, we detected subtle phenotypes, which suggest that these animals compensate for the loss of DJ-1. First, we found a significant upregulation of mitochondrial respiratory enzyme activities, a mechanism known to protect against oxidative stress. Second, a close to significant increase in c-Jun N-terminal kinase 1 phosphorylation in old DJ-1-deficient mice hints at a differential activation of neuronal cell survival pathways. Third, as no change in the density of tyrosine hydroxylase (TH)-positive terminals in the striatum was observed, the remaining dopamine-producing neurons likely compensate by increasing axonal sprouting. In summary, the present data suggest that DJ-1 is implicated in major non-motor symptoms of PD appearing in the early phases of the disease-such as subtle impairments in motivated behaviour and cognition-and that under basal conditions the loss of DJ-1 is compensated.

Details

show
hide
Language(s): eng - English
 Dates: 2010-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 475610
ISI: 000276604800006
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Genes Brain and Behavior
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 9 (3) Sequence Number: - Start / End Page: 305 - 317 Identifier: ISSN: 1601-1848