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  Dissociation of within- and between-Session Extinction of Conditioned Fear

Plendl, W., & Wotjak, C. T. (2010). Dissociation of within- and between-Session Extinction of Conditioned Fear. Journal of Neuroscience, 30(14), 4990-4998.

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 Urheber:
Plendl, W., Autor
Wotjak, C. T.1, Autor           
Affiliations:
1AG Wotjak, Carsten, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607166              

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 Zusammenfassung: Recent findings obtained in patients with phobias or trauma-related anxiety disorders raise doubts concerning the interrelation between acute fear relief during an exposure-based therapeutic session and beneficial treatment progress. In a mouse model explicit for exposure therapy, we challenge the view that within-session fear reduction is the turning point for relearning of a stimulus-threat association. Even though within-session extinction of auditory-cued fear memory was identical for prolonged and spaced tone presentations, only the latter caused between-session extinction. Furthermore, spaced tone presentations led to between-session extinction even in the complete absence of within-session extinction, as observed for remote fear memories and in case of abolished cannabinoid receptor type 1 signaling. Induction of between-session extinction was accompanied by an increase in the number of c-Fos-positive neurons within the basolateral amygdala, the cingulate cortex, and the dentate gyrus, independent of the level of within-session extinction. Together, our findings demonstrate that within-session extinction is neither sufficient nor essential for between-session extinction, thus calling for a reconsideration of current concepts underlying exposure-based therapies.

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Sprache(n): eng - English
 Datum: 2010-04-07
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: -
 Identifikatoren: eDoc: 475611
ISI: 000276414800019
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Titel: Journal of Neuroscience
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 30 (14) Artikelnummer: - Start- / Endseite: 4990 - 4998 Identifikator: ISSN: 0270-6474