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  Communication: Protein Structure in the Gas Phase: The Influence of Side-Chain Microsolvation

Warnke, S., Helden, G. v., & Pagel, K. (2013). Communication: Protein Structure in the Gas Phase: The Influence of Side-Chain Microsolvation. Journal of the American Chemical Society, 135(4), 1177-1180. doi:10.1021/ja308528d.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-7AE1-E Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0015-8D6E-5
Genre: Journal Article

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ja-2012-08528d R2_manuscript.pdf (Any fulltext), 3MB
 
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ja-2012-08528d R2_SI.pdf (Supplementary material), 2MB
 
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 Creators:
Warnke, Stephan1, Author           
Helden, Gert von1, Author           
Pagel, Kevin1, Author           
Affiliations:
1Molecular Physics, Fritz Haber Institute, Max Planck Society, ou_634545              

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 Abstract: There is ongoing debate about the extent to which protein structure is retained after transfer into the gas phase. Here, using ion-mobility spectrometry, we investigated the impact of side-chain–backbone interactions on the structure of gas-phase protein ions by noncovalent attachment of crown ethers (CEs). Our results indicate that in the absence of solvent, secondary interactions between charged lysine side chains and backbone carbonyls can significantly influence the structure of a protein. Once the charged residues are capped with CEs, certain charge states of the protein are found to undergo significant structural compaction.

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Language(s): eng - English
 Dates: 2012-08-282013-01-152013-01-152013-01-30
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/ja308528d
 Degree: -

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Title: Journal of the American Chemical Society
  Other : J. Am. Chem. Soc.
  Abbreviation : JACS
Source Genre: Journal
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Publ. Info: American Chemical Society
Pages: - Volume / Issue: 135 (4) Sequence Number: - Start / End Page: 1177 - 1180 Identifier: ISSN: 0002-7863
CoNE: https://pure.mpg.de/cone/journals/resource/954925376870