de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
 
 
DownloadE-Mail
  Meiotic Prophase Requires Proteolysis of M Phase Regulators Mediated by the Meiosis-Specific APC/C-Ama1

Okaz, E., Argüello-Miranda, O., Bogdanova, A., Vinod, P. K., Lipp, J. J., Markova, Z., et al. (2012). Meiotic Prophase Requires Proteolysis of M Phase Regulators Mediated by the Meiosis-Specific APC/C-Ama1. CELL, 151(3), 603-618. doi:10.1016/j.cell.2012.08.044.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-7761-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-7762-4
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Okaz, Elwy1, Author
Argüello-Miranda, Orlando2, Author              
Bogdanova, Aliona2, Author              
Vinod, P. K.1, Author
Lipp, Jesse J.1, Author
Markova, Zuzana2, Author              
Zagoriy, Ievgeniia2, Author              
Novak, Bela1, Author
Zachariae, Wolfgang2, Author              
Affiliations:
1external, escidoc:persistent22              
2Zachariae, Wolfgang / Chromosome Biology, Max Planck Institute of Biochemistry, Max Planck Society, escidoc:1565176              

Content

show
hide
Free keywords: ANAPHASE PROMOTING COMPLEX/CYCLOSOME; SYNAPTONEMAL COMPLEX-FORMATION; DOUBLE-STRAND BREAKS; SACCHAROMYCES-CEREVISIAE; MOLECULAR-BIOLOGY; YEAST MEIOSIS; BUDDING YEAST; FHA DOMAIN; PROTEIN; KINASE
 Abstract: Whereas proliferating cells enter M phase shortly after DNA replication, the first M phase of meiosis is preceded by an extended prophase in which homologous chromosomes undergo recombination. Exit from prophase I is controlled by the recombination checkpoint (RC), which, in yeast, represses the meiosis-specific transcription factor Ndt80 required for the expression of B-type cyclins and other M phase regulators. We show that an extended prophase I additionally requires the suppression of latent, mitotic cell-cycle controls by the anaphase-promoting complex (APC/C) and its meiosis-specific activator Ama1, which trigger the degradation of M phase regulators and Ndd1, a subunit of a mitotic transcription factor. ama1 Delta mutants exit from prophase I prematurely and independently of the RC, which results in recombination defects and chromosome missegregation. Thus, control of prophase I by meiotic mechanisms depends on the suppression of the alternative, mitotic mechanisms by a meiosis-specific form of the APC/C.

Details

show
hide
Language(s): eng - English
 Dates: 2012-10-26
 Publication Status: Published in print
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: CELL
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 151 (3) Sequence Number: - Start / End Page: 603 - 618 Identifier: ISSN: 0092-8674