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  Nuclear deformation characterizes Werner syndrome cells

Adelfalk, C., Scherthan, H., Hirsch-Kauffmann, M., & Schweiger, M. (n.d.). Nuclear deformation characterizes Werner syndrome cells. Latvian Society for Cell Biology, 1032-1037. doi:10.1016/j.cellbi.2005.10.011.

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Genre: Journal Article
Alternative Title : Cell Biol Int.

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CellbiolInt_sdarticle.pdf (Any fulltext), 377KB
 
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 Creators:
Adelfalk, Caroline1, Author           
Scherthan, Harry1, Author           
Hirsch-Kauffmann, Monica, Author
Schweiger, Manfred2, Author
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
2Max Planck Society, ou_persistent13              

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Free keywords: Cytochalasin B Lamin Nuclear deformation Werner syndrome
 Abstract: Mutations in the lamin A gene have been shown, among other defects, to give rise to Hutchinson-Gilford progeria syndrome (HGPS) and to atypical Werner syndrome (WS), both of which are progeroid disorders. Here, we have investigated well-characterized WS patient cell strains that are compound heterozygous for mutations in the WRN gene. As in HGPS and in atypical WS, we found nuclear deformations to be characteristic of all cell strains studied. In WS cells centrosome number, assembly of the nuclear lamina and nuclear pore distribution occurred normally. Furthermore, nuclear deformations were not associated with a defect in lamin A expression. We propose that nuclear deformation is a universal characteristic of progeroid cells and may result from slow cell cycle progression.

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Language(s): eng - English
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 Identifiers: eDoc: 268552
DOI: 10.1016/j.cellbi.2005.10.011
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Title: Latvian Society for Cell Biology
Source Genre: Issue
 Creator(s):
Erenpreisa, J., Editor
Latvian Society for Cell Biology, Editor  
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 1032 - 1037 Identifier: -

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Title: Cell Biology International
  Alternative Title : Cell Biol Int.
Source Genre: Journal
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Pages: - Volume / Issue: 29 (12) Sequence Number: - Start / End Page: - Identifier: ISSN: 1065-6995