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  Biogenesis of T Pili in Agrobacterium tumefaciens Requires Precise VirB2 Propilin Cleavage and Cyclization

Lai, E.-M., Eisenbrandt, R., Kalkum, M., Lanka, E., & Kado, C. I. (2002). Biogenesis of T Pili in Agrobacterium tumefaciens Requires Precise VirB2 Propilin Cleavage and Cyclization. Journal of Bacteriology, 184(1), 327-330.

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Genre: Journal Article
Alternative Title : J Bacteriol

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 Creators:
Lai, Erh-Min, Author
Eisenbrandt, Ralf, Author
Kalkum, Markus, Author
Lanka, Erich1, Author
Kado, Clarence I., Author
Affiliations:
1Max Planck Society, ou_persistent13              

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 Abstract: VirB2 propilin is processed by the removal of a 47-amino-acid signal peptide to generate a 74-amino-acid peptide product in both Escherichia coli and Agrobacterium tumefaciens. The cleaved VirB2 protein is further cyclized to form the T pilin in A. tumefaciens but not in E. coli. Mutations in the signal peptidase cleavage sequence of VirB2 propilin cause the formation of aberrant T pilin and also severely attenuate virulence. No T pilus was observed in these mutants. The potential role of the exact VirB2 propilin cleavage and cyclization in T pilus biogenesis and virulence is discussed.

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Language(s): eng - English
 Dates: 2002-01
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 24566
 Degree: -

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Title: Journal of Bacteriology
  Alternative Title : J Bacteriol
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 184 (1) Sequence Number: - Start / End Page: 327 - 330 Identifier: -