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  No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals

Patkar, A. A., Berrettini, W. H., Hoehe, M. R., Hill, K. P., Gottheil, E., Thornton, C. C., et al. (2002). No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals. Psychiatric Genetics, 12(3), 161-164.

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Patkar, Ashwin A., Autor
Berrettini, Wade H., Autor
Hoehe, Margret R.1, Autor
Hill, Kevin P., Autor
Gottheil, Edward, Autor
Thornton, Charles C., Autor
Weinstein, Stephen P., Autor
Affiliations:
1Max Planck Society, ou_persistent13              

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Schlagwörter: cocaine dependence; serotonin transporter, gene; polymorphisms; African-American; variable number tandem repeat
 Zusammenfassung: Genetic research of cocaine abuse has been relatively limited among the African-American population. Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American individuals. One hundred and fifty-six cocaine-dependent subjects and 82 controls were studied. Polymerase chain reaction-based genotyping of a variable-number-tandem-repeat (VNTR) marker yielded three alleles designated 12, 10 and 9. Genotype and allele frequencies were compared using chi-square analyses. We found no differences between subjects and controls with respect to genotype distribution (cocaine: 12/12 = 50%, 10/12 = 35.3%, 10/10 = 13.5%, 9/12 = 1.3%; controls: 12/12 = 42.7%, 10/12 = 39.0%, 10/10 = 17.1%, 9/12 = 1.2%). Similarly, allele frequencies of the VNTR marker did not differ between the two groups (cocaine: 12 = 68.3%, 10 = 31.1%, 9 = 0.6%; controls: 12 = 62.8%, 10 = 36.6%, 9 = 0.6%). Our findings do not seem to support a relationship between VNTR polymorphisms and cocaine dependence among African-American patients. Further studies involving larger samples are required to confirm our results.

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Sprache(n): eng - English
 Datum: 2002-01-22
 Publikationsstatus: Erschienen
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 Identifikatoren: eDoc: 27698
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Titel: Psychiatric Genetics
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 12 (3) Artikelnummer: - Start- / Endseite: 161 - 164 Identifikator: -