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  Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals

Cowell, I. G., Aucott, R., Mahadevaiah, S. K., Burgoyne, P. S., Huskisson, N., Bongiorni, S., et al. (2002). Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals. Chromosoma, 111(1), 22-36.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8C66-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8C67-3
Genre: Journal Article

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 Creators:
Cowell, Ian G., Author
Aucott, Rebecca, Author
Mahadevaiah, Shantha K., Author
Burgoyne, Paul S., Author
Huskisson, Neville, Author
Bongiorni, Silvia, Author
Prantera, Giorgio, Author
Fanti, Laura, Author
Pimpinelli, Sergio, Author
Wu, Rong, Author
Gilbert, David M., Author
Shi, Wei, Author
Fundele, Reinald1, Author              
Morrison, Harris, Author
Jeppesen, Peter, Author
Singh, Prim B., Author
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, escidoc:1433549              

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 Abstract: We show that methylated lysine 9 of histone H3 (Me9H3) is a marker of heterochromatin in divergent animal species. It localises to both constitutive and facultative heterochromatin and replicates late in S-phase of the cell cycle. Significantly, Me9H3 is enriched in the inactive mammalian X chromosome (Xi) in female cells, as well as in the XY body during meiosis in the male, and forms a G-band pattern along the arms of the autosomes. Me9H3 is a constituent of imprinted chromosomes that are repressed. The paternal and maternal pronuclei in one-cell mouse embryos show a striking non-equivalence in Me9H3: the paternal pronucleus contains no immunocytologically detectable Me9H3. The levels of Me9H3 on the parental chromosomes only become equivalent after the two-cell stage. Finally, we provide evidence that Me9H3 is neither necessary nor sufficient for localisation of heterochromatin protein 1 (HP1) to chromosomal DNA.

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Language(s): eng - English
 Dates: 2002-01-31
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 24157
 Degree: -

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Title: Chromosoma
Source Genre: Journal
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Pages: - Volume / Issue: 111 (1) Sequence Number: - Start / End Page: 22 - 36 Identifier: -