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  Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals

Cowell, I. G., Aucott, R., Mahadevaiah, S. K., Burgoyne, P. S., Huskisson, N., Bongiorni, S., et al. (2002). Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals. Chromosoma, 111(1), 22-36.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8C66-5 Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8C67-3
Genre: Zeitschriftenartikel

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 Urheber:
Cowell, Ian G., Autor
Aucott, Rebecca, Autor
Mahadevaiah, Shantha K., Autor
Burgoyne, Paul S., Autor
Huskisson, Neville, Autor
Bongiorni, Silvia, Autor
Prantera, Giorgio, Autor
Fanti, Laura, Autor
Pimpinelli, Sergio, Autor
Wu, Rong, Autor
Gilbert, David M., Autor
Shi, Wei, Autor
Fundele, Reinald1, Autor              
Morrison, Harris, Autor
Jeppesen, Peter, Autor
Singh, Prim B., Autor
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, escidoc:1433549              

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 Zusammenfassung: We show that methylated lysine 9 of histone H3 (Me9H3) is a marker of heterochromatin in divergent animal species. It localises to both constitutive and facultative heterochromatin and replicates late in S-phase of the cell cycle. Significantly, Me9H3 is enriched in the inactive mammalian X chromosome (Xi) in female cells, as well as in the XY body during meiosis in the male, and forms a G-band pattern along the arms of the autosomes. Me9H3 is a constituent of imprinted chromosomes that are repressed. The paternal and maternal pronuclei in one-cell mouse embryos show a striking non-equivalence in Me9H3: the paternal pronucleus contains no immunocytologically detectable Me9H3. The levels of Me9H3 on the parental chromosomes only become equivalent after the two-cell stage. Finally, we provide evidence that Me9H3 is neither necessary nor sufficient for localisation of heterochromatin protein 1 (HP1) to chromosomal DNA.

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Sprache(n): eng - Englisch
 Datum: 2002-01-31
 Publikationsstatus: Im Druck publiziert
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 24157
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Titel: Chromosoma
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 111 (1) Artikelnummer: - Start- / Endseite: 22 - 36 Identifikator: -