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  Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region

Sudbrak, R., Reinhardt, R., Hennig, S., Günther, E., & Walter, L. (2002). Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region. Immunogenetics, 54(10), 699-704.

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Sudbrak, Ralf1, Autor           
Reinhardt, Richard2, Autor           
Hennig, Steffen1, Autor           
Günther, Eberhard, Autor
Walter, Lutz, Autor
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433552              

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Schlagwörter: mhc, evolution, comparative sequence analysis, rhesus macaque
 Zusammenfassung: The sequence-based map of a part of the rhesus macaque major histocompatibility complex (MHC) extended class II region is presented. The sequenced region encompasses 67,401 bp and contains the SACM2L, RING1, FABGL and KE4 genes, as well as the HTATSF1-like and ZNF-like pseudogenes. Similar to human, but different from rat and mouse, no class I genes are found in the SACM2L-RING1 interval. The rhesus macaque extended MHC class II region shows a high degree of conservation of exonic as well as intronic and intergenic sequences compared with the respective human region. It is concluded that this particular genomic organization of the extended class II region--i.e., the absence of class I genes and the presence of the HTATSF1-like and ZNF-like pseudogenes--can be traced back to a common ancestor of humans and rhesus macaques about 23 million years ago.

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Sprache(n): eng - English
 Datum: 2002-12-10
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 24572
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Titel: Immunogenetics
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 54 (10) Artikelnummer: - Start- / Endseite: 699 - 704 Identifikator: -