Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus 
agrarius and A-flavicollis in nature

Klempa, Boris; Schmidt, Heiko A.; Ulrich, Rainer; Kaluz, Stefan; Labuda, Milan; Meisel, Helga; Hjelle, Brian; Krüger, Detlev H.

doi:10.1128/JVI.77.1.804-809.2003

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Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A-flavicollis in nature

Klempa, B., Schmidt, H. A., Ulrich, R., Kaluz, S., Labuda, M., Meisel, H., et al. (2003). Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A-flavicollis in nature. Journal of Virology, 77(1), 804-809. doi:10.1128/JVI.77.1.804-809.2003.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8AFF-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8B00-8

Genre: Journal Article

Alternative Title : J. Virol.

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Creators:
Klempa, Boris, Author
Schmidt, Heiko A.¹, Author
Ulrich, Rainer, Author
Kaluz, Stefan, Author
Labuda, Milan, Author
Meisel, Helga, Author
Hjelle, Brian, Author
Krüger, Detlev H., Author

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1Max Planck Society, ou_persistent13

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Abstract: Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa strains which fell into two distinct genetic lineages. Molecular phylogenetic analyses gave evidence for genetic reassortment between S and M segments of DOBV-Af and DOBV-Aa and indicated homologous recombination events in DOBV evolution. DOBV-Af and DOBV-Aa are distinct but also subject to genetic exchanges that affect their evolutionary trajectories.

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Language(s): eng - English

Dates: Date issued: 2003-01

Publication Status: Issued

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Identifiers: eDoc: 175842
ISI: 000179855400085
DOI: 10.1128/JVI.77.1.804-809.2003

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Title: Journal of Virology

Alternative Title : J. Virol.

Source Genre: Journal

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Pages: - Volume / Issue: 77 (1) Sequence Number: - Start / End Page: 804 - 809 Identifier: ISSN: 0022-538X