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  The endocrine regulation of aging by insulin-like signals

Tatar, M., Bartke, A., & Antebi, A. (2003). The endocrine regulation of aging by insulin-like signals. Science, 299(5611), 1346-1351. doi:10.1126/science.1081447.

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Genre: Journal Article
Alternative Title : Science

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 Creators:
Tatar, Marc, Author
Bartke, Andrzej, Author
Antebi, Adam1, Author           
Affiliations:
1Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433554              

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 Abstract: Reduced signaling of insulin-like peptides increases the life-span of nematodes, flies, and rodents. In the nematode and the fly, secondary hormones downstream of insulin-like signaling appear to regulate aging. In mammals, the order in which the hormones act is unresolved because insulin, insulin-like growth factor-1, growth hormone, and thyroid hormones are interdependent. In all species examined to date, endocrine manipulations can slow aging without concurrent costs in reproduction, but with inevitable increases in stress resistance. Despite the similarities among mammals and invertebrates in insulin-like peptides and their signal cascade, more research is needed to determine whether these signals control aging in the same way in all the species by the same mechanism.

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Language(s): eng - English
 Dates: 2003-02-28
 Publication Status: Issued
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 173757
ISI: 000181192300039
DOI: 10.1126/science.1081447
 Degree: -

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Title: Science
  Alternative Title : Science
Source Genre: Journal
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Pages: - Volume / Issue: 299 (5611) Sequence Number: - Start / End Page: 1346 - 1351 Identifier: ISSN: 0036-8075