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  Genome-wide array analysis of normal and malformed human hearts

Kaynak, B., von Heydebreck, A., Mebus, S., Seelow, D., Hennig, S., Vogel, J., et al. (2003). Genome-wide array analysis of normal and malformed human hearts. Circulation, 107(19), 2467-2474. doi:10.1161/01.CIR.0000066694.21510.E2.

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Genre: Zeitschriftenartikel
Alternativer Titel : Circulation

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Kaynak, Bogac1, Autor
von Heydebreck, Anja1, Autor
Mebus, Sigrun, Autor
Seelow, Dominik2, Autor           
Hennig, Steffen3, Autor           
Vogel, Jan, Autor
Sperling, Hans-Peter, Autor
Pregla, Reinhard, Autor
Alexi-Meskishvili, Vladimir, Autor
Hetzer, Roland, Autor
Lange, Peter E.1, Autor
Vingron, Martin4, Autor           
Lehrach, Hans3, Autor           
Sperling, Silke3, Autor           
Affiliations:
1Max Planck Society, ou_persistent13              
2Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              
3Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
4Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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Schlagwörter: heart defects, congenital, hypertrophy, atrium, ventricle, molecular biology
 Zusammenfassung: Background We present the first genome-wide cDNA array analysis of human congenitally malformed hearts and attempted to partially elucidate these complex phenotypes. Most congential heart defects, which account for the largest number of birth defects in humans, represent complex genetic disorders. As a consequence of the malformation, abnormal hemodynamic features occur and cause an adaptation process of the heart. Methods and Results The statistical analysis of our data suggests distinct gene expression profiles associated with tetralogy of Fallot, ventricular septal defect, and right ventricular hypertrophy. Applying correspondence analysis, we could associate specific gene functions to specific phenotypes. Furthermore, our study design allows the suggestion that alterations associated with primary genetic abnormalities can be distinguished from those associated with the adaptive response of the heart to the malformation (right ventricular pressure overload hypertrophy). We provide evidence for the molecular transition of the hypertrophic right ventricle to normal left ventricular characteristics. Furthermore, we present data on chamber-specific gene expression. Conclusions Our findings propose that array analysis of malformed human hearts opens a new window to understand the complex genetic network of cardiac development and adaptation. For detailed access, see the online-only Data Supplement. Data Supplement: Genome-Wide Array Analysis of Normal and Malformed Human Hearts: Supplementary Information (HTML page)

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Sprache(n): eng - English
 Datum: 2003-05-20
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 174662
ISI: 000183014500015
DOI: 10.1161/01.CIR.0000066694.21510.E2
 Art des Abschluß: -

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Titel: Circulation
  Alternativer Titel : Circulation
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 107 (19) Artikelnummer: - Start- / Endseite: 2467 - 2474 Identifikator: ISSN: 0009-7322