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  Identification of downstream targets of the nodal signaling pathway.

Bennett, J., Joubin, K., Cheng, S., Aanstad, P., Lehrach, H., & Schier, A. F. (2003). Identification of downstream targets of the nodal signaling pathway. Developmental Biology, 259(2), 527-527.

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Genre: Zeitschriftenartikel
Alternativer Titel : Dev. Biol.

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 Urheber:
Bennett, James, Autor
Joubin, Kathy, Autor
Cheng, Simon, Autor
Aanstad, Pia1, Autor
Lehrach, Hans2, Autor           
Schier, Alexander F., Autor
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Zusammenfassung: Nodal signaling is critical for a variety of processes during vertebrate development, including gastrulation and left—right patterning. Although many of the molecules that play a role in the transduction of Nodal signals are known, the current list of genes known to be regulated by Nodal signals is incomplete. We identified putative Nodal regulated genes by differential RNA hybridization against a zebrafish cDNA library of about 14,000 cDNAs. Putative Nodal-regulated genes were also identified by screening zebrafish gene expression databases for genes expressed in the margin or shield of early gastrula-stage embryos. Putative Nodal-regulated genes were then screened by in situ hybridization against wild-type and maternal-zygotic one eyed pinhead embryos, which lack all Nodal signaling. This led to the identification of 57 unique Nodal-regulated genes. We are currently analyzing the function and regulation of these genes.

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Sprache(n): eng - English
 Datum: 2003-07-15
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 168935
ISI: 000184373300343
 Art des Abschluß: -

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Titel: Developmental Biology
  Alternativer Titel : Dev. Biol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 259 (2) Artikelnummer: - Start- / Endseite: 527 - 527 Identifikator: ISSN: 0012-1606