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  Next generation of protein microarray support materials: Evaluation for protein and antibody microarray applications

Angenendt, P., Glökler, J., Sobek, J., Lehrach, H., & Cahill, D. J. (2003). Next generation of protein microarray support materials: Evaluation for protein and antibody microarray applications. Journal of Chromatography A, 1009(1-2), 97-104.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-89D0-2 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-89D1-F
Genre: Journal Article
Alternative Title : J. Chromatogr. A

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 Creators:
Angenendt, Philipp1, Author           
Glökler, Jörn1, Author           
Sobek, Jens2, Author
Lehrach, Hans1, Author           
Cahill, Dolores J.2, Author
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Max Planck Society, ou_persistent13              

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Free keywords: chip technology, proteins, antibodiesChip technology
 Abstract: The performance of protein and antibody microarrays is dependent on various factors, one of which is the use of an appropriate microarray surface for the immobilisation of either protein or antibody samples. We have investigated the properties of seven new surfaces in the context of both protein and antibody microarray technology. We have demonstrated the functionality of all new slide coatings and investigated the mean signal to spotted concentration ratio, determined detection limits and calculated coefficients of variation. Moreover, new concepts for slide coatings such as dendrimer and poly(ethylene glycol)-epoxy slides were evaluated and improved qualities of novel slide surfaces were observed. Optimal slide coatings for antibody and protein chips were proposed and the requirements for both technologies were discussed.

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Language(s): eng - English
 Dates: 2003-08-15
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 168894
ISI: 000184972400010
 Degree: -

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Title: Journal of Chromatography A
  Alternative Title : J. Chromatogr. A
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 1009 (1-2) Sequence Number: - Start / End Page: 97 - 104 Identifier: ISSN: 0021-9673