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  HC gp-39 gene is upregulated in glioblastomas

Shostak, K., Labunskyy, V., Dmitrenko, V., Malisheva, T., Shamayev, M., Rozumenko, V., et al. (2003). HC gp-39 gene is upregulated in glioblastomas. Cancer Letters, 198(2), 203-210. doi:10.1016/S0304-3835(03)00310-0.

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Genre: Zeitschriftenartikel
Alternativer Titel : Cancer Lett.

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 Urheber:
Shostak, Katherina, Autor
Labunskyy, Vyacheslav, Autor
Dmitrenko, Vladimir, Autor
Malisheva, Tatiana, Autor
Shamayev, Michail, Autor
Rozumenko, Vladimir, Autor
Zozulya, Yuriy, Autor
Zehetner, Guenther1, Autor           
Kavsan, Vadym, Autor
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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Schlagwörter: brain tumor, astrocytic gliomas, glioblastoma multiforme, electronic subtraction, differential expression, HC gp-39 gene
 Zusammenfassung: Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression (SAGE). Analysis revealed HC gp-39 among the genes with the most pronounced changes of expression in tumor cells. Northern hybridization confirmed the results of computer analysis and showed that enhanced expression of the HC gp-39 gene was mainly in GBMs and occasionally in anaplastic astrocytomas. Neither SAGE nor Northern analysis revealed the presence of HC gp-39 mRNA in the glioblastoma cell line, thus the detection of increased quantities of this mRNA in GBMs may be associated with activated macrophages. Since the numbers of infiltrating macrophages and small vessel density are higher in glioblastomas than in anaplastic astrocytomas or astrocytomas, the HC gp-39 gene can be used as a molecular marker in the analysis of malignant progression of astrocytic gliomas.

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Sprache(n): eng - English
 Datum: 2003-08-20
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 194808
ISI: 000186363700010
DOI: 10.1016/S0304-3835(03)00310-0
 Art des Abschluß: -

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Titel: Cancer Letters
  Alternativer Titel : Cancer Lett.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 198 (2) Artikelnummer: - Start- / Endseite: 203 - 210 Identifikator: ISSN: 0304-3835