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  ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer

Himmelfarb, M., Klopocki, E., Grube, S., Staub, E., Klaman, I., Hinzmann, B., et al. (2004). ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer. Cancer Letters: an International Journal Providing a Forum for Original and Pertinent Contributions in Cancer Research, 204(1), 69-77. doi:10.1016/j.canlet.2003.09.011.

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Genre: Zeitschriftenartikel
Alternativer Titel : Cancer Lett

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 Urheber:
Himmelfarb, Marina, Autor
Klopocki, Eva1, Autor           
Grube, Susanne, Autor
Staub, Eike2, Autor
Klaman, Irina, Autor
Hinzmann, Bernd, Autor
Kristiansen, Glen, Autor
Rosenthal, André, Autor
Dürst, Matthias, Autor
Dahl, Edgar, Autor
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              
2Max Planck Society, ou_persistent13              

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Schlagwörter: Inter-small alpha, Greek-trypsin inhibitor; ITI heavy chain; Breast cancer; Tumor suppressor gene
 Zusammenfassung: The inter-small alpha, Greek-trypsin inhibitor (ITI) family constitutes a group of proteins built up from one light chain and a variable set of heavy chains. Originally identified as plasma protease inhibitors, recent data indicate that ITI plays a role in extracellular matrix (ECM) stabilization and in prevention of tumor metastasis. Here we describe cloning as well as phylogenetic and expression analysis of a novel member of the heavy chain gene family, ITIH5. ITIH5 contains the two domains conserved in all known ITIHs, the vault protein inter-alpha-trypsin (VIT) domain and a von Willebrand type A (vWA) domain. However, ITIH5 diverged early from a common ancestor of the other subfamilies. We found strong downregulation of ITIH5 expression in breast tumors by real-time PCR and RNA in situ hybridization. While normal breast epithelial cells clearly express ITIH5, expression is consistantly lost or strongly downregulated in invasive ductal carcinoma. ITIH5 mRNA was neither detectable in cancerous nor benign breast cell lines. We propose that loss of ITIH5 expression may be involved in breast cancer development.

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Sprache(n): eng - English
 Datum: 2004-02-10
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 226557
DOI: 10.1016/j.canlet.2003.09.011
 Art des Abschluß: -

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Titel: Cancer Letters : an International Journal Providing a Forum for Original and Pertinent Contributions in Cancer Research
  Alternativer Titel : Cancer Lett
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 204 (1) Artikelnummer: - Start- / Endseite: 69 - 77 Identifikator: ISSN: 0304-3835