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  Array technology and proteomics in autoimmune diseases

Krenn, V., Petersen, I., Haeupl, T., Koepenik, A., Blind, C., Dietel, M., et al. (2004). Array technology and proteomics in autoimmune diseases. Proteomics in Pathology, Research and Practice, 95-103. doi:10.1016/j.prp.2004.02.005.

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Genre: Zeitschriftenartikel
Alternativer Titel : Pathol., Res. Pract.

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Urheber

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 Urheber:
Krenn, Veit, Autor
Petersen, Iver, Autor
Haeupl, Thomas, Autor
Koepenik, Axel, Autor
Blind, Christiane, Autor
Dietel, Manfred, Autor
Konthur, Zoltan1, Autor
Skriner, Karl, Autor
Affiliations:
1Max Planck Society, ou_persistent13              

Inhalt

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Schlagwörter: Tissue array; Proteomics; Rheumatoid arthritis; Osteoarthritis; Synovitis score
 Zusammenfassung: Two new technologies (tissue microarrays (TMAs) and proteomics) have generated a great amount of data in life science. High-density TMAs allow for the simultaneous analysis of proteins and RNA by various methods (immunohistochemistry, in situ hybridization, FISH) on a large scale and under highly standardized conditions. Proteomics includes a variety of techniques that are partly high throughput. These techniques aim at the innovation of proteins, the description of the domain structure, the determination of protein sequences and epitope characterization, and ultimately the definition of protein function and protein reactivities in immunologic processes. Proteins that have been characterized accordingly require validation mostly at the morphologic level of defined tissue, linking proteomics to TMAs. In autoimmune diseases, array-based antigenic fingerprinting of autoantibodies will drive the development and the selection of antigen-specific diagnostic tools and therapies. The powerful combination of genomics and proteomics formed in tissue arrays has the potential to change the way the biology of autoimmunity is studied. Novel targets of drug discovery, based on antigen-specific therapies to induce anergy, or regulatory T-cells using the targeted autoantigens of individual patients could be developed in the coming decades.

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Sprache(n): eng - English
 Datum: 2004-04-30
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 229541
DOI: 10.1016/j.prp.2004.02.005
 Art des Abschluß: -

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Quelle 1

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Titel: Proteomics in Pathology, Research and Practice
Genre der Quelle: Heft
 Urheber:
Roecken, Christoph, Herausgeber
Affiliations:
-
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: 95 - 103 Identifikator: -

Quelle 2

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Titel: Pathology, Research and Practice : Official Journal of the European Society of Pathology
  Alternativer Titel : Pathol., Res. Pract.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 200 Artikelnummer: - Start- / Endseite: - Identifikator: ISSN: 0344-0338