ausblenden:
Schlagwörter:
rodent animal model; chondrocyte; growth plate; parathyroid hormone/parathyroid hormone-related protein; hedgehog
Zusammenfassung:
The role of Hedgehogs (Hh) in murine skeletal development was studied by overexpressing human Sonic Hedgehog (SHH) in chondrocytes of transgenic mice using the collagen II promoter/enhancer. Overexpression caused a lethal craniorachischisis with major alterations in long bones because of defects in chondrocyte differentiation.