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  Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories

Belyakin, S. N., Christophides, G. K., Alekseyenko, A. A., Kriventseva, E. V., Belyaeva, E. S., Nanayev, R. A., et al. (2005). Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories. Proceedings of the National Academy of Sciences, 107(23), 8269-8274. doi:10.1073/pnas.0502702102.

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Genre: Journal Article
Alternative Title : PNAS

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 Creators:
Belyakin, Stepan N., Author
Christophides, George K., Author
Alekseyenko, Artyom A., Author
Kriventseva, Evgenia V., Author
Belyaeva, Elena S., Author
Nanayev, Roman A., Author
Makunin, Igor V., Author
Hild, M., Author
Beckmann, B., Author
Haas, Stefan A.1, Author
Koch, B., Author
Solovyev, V., Author
Busold, C., Author
Fellenberg, K., Author
Boutros, M., Author
Vingron, Martin2, Author           
Sauer, F., Author
Hoheisel, J. D., Author
Paro, R., Author
Heidelberg Fly Array Consortium, Editor  
Affiliations:
1Max Planck Society, ou_persistent13              
2Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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Free keywords: DNA replication polytene chromosomes suppressor of underreplication transcriptional silencing
 Abstract: In Drosophila polytene chromosomes, most late-replicating regions remain underreplicated. A loss-of-function mutant of the suppressor of underreplication [Su(UR)] gene suppresses underreplication (UR), whereas extra copies of this gene enhance the level and number of regions showing UR. By combining DNA microarray analysis with manipulation of the number of Su(UR) gene copies, we achieved genomic-scale molecular identification of 1,036 genes that are arranged in clusters located in 52 UR chromosomal regions. These regions overlap extensively (96%) but are not completely identical with late-replicating regions of mitotically dividing Kc cells in culture. Reanalysis of published gene expression profiles revealed that genomic regions defined by replication properties include clusters of coordinately expressed genes. Genomic regions that are UR in polytene chromosomes and late replicated in Kc cell chromosomes show a particularly common association with transcriptional territories that are expressed in testis/males but not ovary/females or embryos. An attractive hypothesis for future testing is that factors involved in replication control, such as SU(UR), may interact physically with those involved in epigenetic silencing of transcription territories.

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Language(s): eng - English
 Dates: 2005-04-01
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 264907
DOI: 10.1073/pnas.0502702102
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Title: Proceedings of the National Academy of Sciences
  Alternative Title : PNAS
Source Genre: Journal
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Pages: - Volume / Issue: 107 (23) Sequence Number: - Start / End Page: 8269 - 8274 Identifier: ISSN: 1091-6490