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  The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression

Kasper, G., Vogel, A., Klaman, I., Gröne, J., Petersen, I., Weber, B., et al. (2005). The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression. Cancer Letters, 224(1), 93-103. doi:10.1016/j.canlet.2004.10.004.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-861A-5 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-861B-3
Genre: Zeitschriftenartikel
Alternativer Titel : Cancer Lett

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 Urheber:
Kasper, Grit1, Autor
Vogel, Anke, Autor
Klaman, Irina, Autor
Gröne, Jörn, Autor
Petersen, Iver, Autor
Weber, Birgit, Autor
Castaños-Vélez, Esmeralda, Autor
Staub, Eike1, Autor
Mennerich, Detlev, Autor
Affiliations:
1Max Planck Society, ou_persistent13              

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Schlagwörter: LAPTM4b Expression analysis Multidrug-resistance
 Zusammenfassung: LAPTM4b (lysosome associated protein transmembrane 4 beta) was recently identified as a gene overexpressed in human hepatocellular carcinoma and belongs to the mammalian LAPTM family. By analysing genome-wide expression profiles of microdissected solid tumour samples by the means of Affymetrix GenChip hybridisation, we found LAPTM4b to be upregulated in 88% (23/26) of lung and in 67% (18/27) of colon carcinoma patients. Northern blots revealed additionally an overexpression of LAPTM4b in the majority of carcinomas of the uterus (30/44), breast (27/53) and ovary (11/16). Other members of the LAPTM family were not overexpressed in the investigated tumour samples according to GeneChip hybridisation data. Northen blot and quantitative RT-PCR on different normal tissues, detected highest levels of LAPTM4b mRNA in uterus, heart and skeletal muscle. Due to sequence analysis of bilaterian LAPTM proteins we suggests the presence of four transmembrane helices per protein, which are probably packed together by hydrophobic forces that are excerted by several evolutionary conserved aromatic residues within the α-helices. We discuss an active role for LAPTM4b during disease progression of malignant cells and conclude that its putative dual functional involvement in tumour cell proliferation as well as in multidrug-resistance may represent LAPTM4b as a target suitable for development of novel therapeutic agents.

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Sprache(n): eng - English
 Datum: 2005-06-16
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 265103
DOI: 10.1016/j.canlet.2004.10.004
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Titel: Cancer Letters
  Alternativer Titel : Cancer Lett
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 224 (1) Artikelnummer: - Start- / Endseite: 93 - 103 Identifikator: ISSN: 0304-3835