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  Integrative model of the response of yeast to osmotic shock

Klipp, E., Nordlander, B., Krüger, R., Gennemark, P., & Hohmann, S. (2005). Integrative model of the response of yeast to osmotic shock. Nature Biotechnology, 23(8), 975-982. doi:10.1038/nbt1114.

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Genre: Journal Article
Alternative Title : Nature Biotechnol

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Klipp et al. - Nat Biotechnol.pdf (Any fulltext), 271KB
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Klipp et al. - Nat Biotechnol.pdf
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Klipp, Edda1, Author           
Nordlander, Bodil, Author
Krüger, Roland, Author
Gennemark, Peter, Author
Hohmann, Stefan, Author
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1Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433554              

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 Abstract: Integration of experimental studies with mathematical modeling allows insight into systems properties, prediction of perturbation effects and generation of hypotheses for further research. We present a comprehensive mathematical description of the cellular response of yeast to hyperosmotic shock. The model integrates a biochemical reaction network comprising receptor stimulation, mitogen-activated protein kinase cascade dynamics, activation of gene expression and adaptation of cellular metabolism with a thermodynamic description of volume regulation and osmotic pressure. Simulations agree well with experimental results obtained under different stress conditions or with specific mutants. The model is predictive since it suggests previously unrecognized features of the system with respect to osmolyte accumulation and feedback control, as confirmed with experiments. The mathematical description presented is a valuable tool for future studies on osmoregulation in yeast and—with appropriate modifications—other organisms. It also serves as a starting point for a comprehensive description of cellular signaling.

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Language(s): eng - English
 Dates: 2005-07-17
 Publication Status: Issued
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 Identifiers: eDoc: 271959
DOI: 10.1038/nbt1114
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Title: Nature Biotechnology
  Alternative Title : Nature Biotechnol
Source Genre: Journal
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Pages: - Volume / Issue: 23 (8) Sequence Number: - Start / End Page: 975 - 982 Identifier: ISSN: 1087-0156